ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
Estimated Impact of World Health Organization Latent Tuberculosis Screening Guidelines in a Region With a Low Tuberculosis Incidence: Retrospective Cohort Study.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 31 citations in OpenAlex.
- Observational
- Impact of detection rate and preventive treatment of latent tuberculosis infection on the future burden of tuberculosis among students in shanghai: a predictive study using Markov modeling.BMC public health · 2025Article
- [Tuberculosis Risk and Efficacy of Latent Tuberculosis Infection Treatment among Participants of National Latent Tuberculosis Infection Screening Program].Jugan geon-gang gwa jilbyeong · 2024Article
- The potential association between metabolic disorders and pulmonary tuberculosis: a Mendelian randomization study.European journal of medical research · 2024Article
- Role of latent tuberculosis infection on elevated risk of cardiovascular disease: a population-based cohort study of immigrants in British Columbia, Canada, 1985-2019.Epidemiology and infection · 2023Article
- Impact and benefit-cost ratio of a program for the management of latent tuberculosis infection among refugees in a region of Canada.PloS one · 2022Article
- Prevalence of latent tuberculosis infection among participants of the national LTBI screening program in South Korea - A problem of low coverage rate with current LTBI strategy.Frontiers in public health · 2022Article
- How Well Does TSTin3D Predict Risk of Active Tuberculosis in the Canadian Immigrant Population? An External Validation Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Latent Tuberculosis Infection Screening and Treatment in Congregate Settings (TB FREE COREA): Demographic Profiles of Interferon-Gamma Release Assay Cohort.Journal of Korean medical science · 2021Article
- Risk of active tuberculosis in migrants diagnosed with cancer: a retrospective cohort study in British Columbia, Canada.BMJ open · 2021Article
- Post-tuberculosis mortality risk among immigrants to British Columbia, Canada, 1985-2015: a time-dependent Cox regression analysis of linked immigration, public health, and vital statistics data.Canadian journal of public health = Revue canadienne de sante publique · 2021Article
- Identifying gaps in the quality of latent tuberculosis infection care.Journal of clinical tuberculosis and other mycobacterial diseases · 2020Article
- Article
- Treatment of latent infection to achieve tuberculosis elimination in low-incidence countries.PLoS medicine · 2019Review
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10 authors at 4 institutions in 1 country.
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Abstract
backgroundLatent tuberculosis infection (LTBI) screening and treatment is a key component of the World Health Organization (WHO) EndTB Strategy, but the impact of LTBI screening and treatment at a population level is unclear. We aimed to estimate the impact of LTBI screening and treatment in a population of migrants to British Columbia (BC), Canada.
methodsThis retrospective cohort included all individuals (N = 1 080 908) who immigrated to Canada as permanent residents between 1985 and 2012 and were residents in BC at any time up to 2013. Multiple administrative databases were linked to identify people with risk factors who met the WHO strong recommendations for screening: people with tuberculosis (TB) contact, with human immunodeficiency virus, on dialysis, with tumor necrosis factor-alpha inhibitors, who had an organ/haematological transplant, or with silicosis. Additional TB risk factors included immunosuppressive medications, cancer, diabetes, and migration from a country with a high TB burden. We defined active TB as preventable if diagnosed ≥6 months after a risk factor diagnosis. We estimated the number of preventable TB cases, given optimal LTBI screening and treatment, based on these risk factors.
resultsThere were 16 085 people (1.5%) identified with WHO strong risk factors. Of the 2814 people with active TB, 118 (4.2%) were considered preventable through screening with WHO risk factors. Less than half (49.4%) were considered preventable with expanded screening to include people migrating from countries with high TB burdens, people who had been prescribed immunosuppressive medications, or people with diabetes or cancer.
conclusionsThe application of WHO LTBI strong recommendations for screening would have minimally impacted the TB incidence in this population. Further high-risk groups must be identified to develop an effective LTBI screening and treatment strategy for low-incidence regions.
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