ArticlePloS one2019
Specific clones of Trichomonas tenax are associated with periodontitis.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Assessment of the role of Trichomonas tenax in the etiopathogenesis of human periodontitis: A systematic review.PloS one · 2019Pooled it
- The association between Trichomonas tenax and Entamoeba gingivalis and periimplantitis and periodontitis.Clinical oral investigations · 2026Article
- Exploring the oral microbiome: from traditional techniques to advanced omics and databases.Antonie van Leeuwenhoek · 2026Review
- Beyond Bacteria: The Impact of Protozoa on Periodontal Health.Microorganisms · 2025Review
- Retraction: Deciphering the urinary microbiota repertoire by culturomics reveals mostly anaerobic bacteria from the gut.Frontiers in microbiology · 2025Article
- Retraction: Tobacco smoking affects the salivary gram-positive bacterial population.Frontiers in public health · 2025Article
- Retraction: Among live and dead bacteria, the optimization of sample collection and processing remains essential in recovering gut microbiota components.Frontiers in microbiology · 2025Article
- Oral microbiota in aging and diseases.Life medicine · 2024Review
- Risk factors and approaches for detection ofThe Saudi dental journal · 2024Review
- The oral microbiome: diversity, biogeography and human health.Nature reviews. Microbiology · 2024Review
- Article
- Comparative genomics betweenFrontiers in microbiology · 2024Article
- NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli.PLoS pathogens · 2023Article
- Culturing the Human Oral Microbiota, Updating Methodologies and Cultivation Techniques.Microorganisms · 2023Review
- Article
- Trichomonas tenax induces barrier defects and modulates the inflammatory cytotoxicity of gingival and pulmonary epithelial cells.Parasite (Paris, France) · 2023Article
- Pyopneumothorax Caused byInfection and drug resistance · 2022Article
- Expression of Concern: Specific clones of Trichomonas tenax are associated with periodontitis.PloS one · 2022Article
- Host prediction for disease-associated gastrointestinal cressdnaviruses.Virus evolution · 2022Article
- Pyopneumothorax from coinfection by Trichomonas tenax and Geotrichum capitatum in a child from China: a case report.BMC infectious diseases · 2021Article
Corrections and comments
- Retraction · 2024-10-14Concerns/Issues about Data · Concerns/Issues about Human Subject Welfare · Conflict of Interest · Error in Text · Investigation by Company/Institution · Investigation by Journal/Publisher · Lack of IRB/IACUC Approval and/or Compliance · Objections by Author(s) ·
- Expression of concern · 2022-12-13Investigation by Journal/Publisher · Updated to Retraction ·
- Expression of concern
- Retracted
Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Trichomonas tenax, an anaerobic protist difficult to cultivate with an unreliable molecular identification, has been suspected of involvement in periodontitis, a multifactorial inflammatory dental disease affecting the soft tissue and bone of periodontium. A cohort of 106 periodontitis patients classified by stages of severity and 85 healthy adult control patients was constituted. An efficient culture protocol, a new identification tool by real-time qPCR of T. tenax and a Multi-Locus Sequence Typing system (MLST) based on T. tenax NIH4 reference strain were created. Fifty-three strains of Trichomonas sp. were obtained from periodontal samples. 37/106 (34.90%) T. tenax from patients with periodontitis and 16/85 (18.80%°) T. tenax from control patients were detected by culture (p = 0.018). Sixty of the 191 samples were tested positive for T. tenax by qPCR, 24/85 (28%) controls and 36/106 (34%) periodontitis patients (p = 0.089). By combining both results, 45/106 (42.5%) patients were positive by culture and/or PCR, as compared to 24/85 (28.2%) controls (p = 0.042). A link was established between the carriage in patients of Trichomonas tenax and the severity of the disease. Genotyping demonstrates the presence of strain diversity with three major different clusters and a relation between disease strains and the periodontitis severity (p<0.05). More frequently detected in periodontal cases, T. tenax is likely to be related to the onset or/and evolution of periodontal diseases.
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