Evidence map›Paper›PMID 30856180›Full record

ArticlePLoS neglected tropical diseases2019

A polyvalent coral snake antivenom with broad neutralization capacity.

María Carlina Castillo-Beltrán, Juan Pablo Hurtado-Gómez, Vladimir Corredor-Espinel, Francisco Javier Ruiz-Gómez

Open access · goldAbstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Venomics of the Anchor Coral SnakeTropical medicine and infectious disease · 2026
    Article
  2. Toxins · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. ImprovingF1000Research · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. First Insights into the Venom Composition of Two Ecuadorian Coral Snakes.International journal of molecular sciences · 2022
    Article
  12. Anti-Neurotoxins fromToxins · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

María Carlina Castillo-BeltránGrupo de Investigación en Animales Ponzoñosos y sus Venenos, Grupo de Producción y Desarrollo Tecnológico, Dirección de Producción, Instituto Nacional de Salud, Bogotá, Colombia.
Juan Pablo Hurtado-GómezGrupo de Investigación en Animales Ponzoñosos y sus Venenos, Grupo de Producción y Desarrollo Tecnológico, Dirección de Producción, Instituto Nacional de Salud, Bogotá, Colombia.ORCID 0000-0003-4351-2834
Vladimir Corredor-EspinelParasitology Laboratory, Department of Public Health, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
Francisco Javier Ruiz-GómezGrupo de Investigación en Animales Ponzoñosos y sus Venenos, Grupo de Producción y Desarrollo Tecnológico, Dirección de Producción, Instituto Nacional de Salud, Bogotá, Colombia.ORCID 0000-0002-8418-4243
Instituto Nacional de Salud · COUniversidad Nacional de Colombia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coral snakes of the genus Micrurus have a high diversity and wide distribution in the Americas. Despite envenomings by these animals being uncommon, accidents are often severe and may result in death. Producing an antivenom to treat these envenomings has been challenging since coral snakes are difficult to catch, produce small amounts of venom, and the antivenoms produced have shown limited cross neutralization. Here we present data of cross neutralization among monovalent antivenoms raised against M. dumerilii, M. isozonus, M. mipartitus and M. surinamensis and the development of a new polyvalent coral snake antivenom, resulting from the mix of monovalent antivenoms. Our results, show that this coral snake antivenom has high neutralizing potency and wide taxonomic coverage, constituting a possible alternative for a long sought Pan-American coral snake antivenom.

Indexed as

Coral SnakesCross ReactionsAmericasAnimalsAntiveninsImmunologic FactorsNeutralization TestsAntiveninsImmunologic Factors

Identifiers

PMID30856180
PMCPMC6428337
OpenAlexW2921989974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.