Evidence map›Paper›PMID 30855229›Full record

ArticleeLife2019

A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites.

Nan Jiang, Jeffrey P Rasmussen, Joshua A Clanton, Marci F Rosenberg, Kory P Luedke, Mark R Cronan, Edward D Parker, Hyeon-Jin Kim, Joshua C Vaughan, Alvaro Sagasti and 1 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 59 citations in OpenAlex.

  1. Peripheral mechanisms of tactile sensation in fish.Current opinion in neurobiology · 2026
    Review
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  4. eLife · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nan JiangDepartment of Biology, University of Washington, Seattle, United States.
Jeffrey P RasmussenDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0001-6997-3773
Joshua A ClantonDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Marci F RosenbergDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.
Kory P LuedkeDepartment of Biology, University of Washington, Seattle, United States.
Mark R CronanDepartment of Molecular Genetics and Microbiology, Duke University, Durham, United States.
Edward D ParkerDepartment of Opthalmology, University of Washington, Seattle, United States.
Hyeon-Jin KimDepartment of Chemistry, University of Washington, Seattle, United States.
Joshua C VaughanDepartment of Chemistry, University of Washington, Seattle, United States.ORCID 0000-0002-6550-8935
Alvaro SagastiDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.ORCID 0000-0002-6823-0692
Jay Z ParrishDepartment of Biology, University of Washington, Seattle, United States.ORCID 0000-0002-0656-9148
University of Washington · USUniversity of California, Los Angeles · USDuke University · US

Funding

Vision Research CoreP30EY001730 · NEI · UNIVERSITY OF WASHINGTON · PI JAMES Bryant HURLEY · 1985 to 2026
$23.5M
Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Structural and functional coupling of epidermis to somatosensory neurons in DrosophilaR01NS076614 · NINDS · UNIVERSITY OF WASHINGTON · PI BAUTISTA, DIANA MICHELE, PARRISH, JAY Z · 2011 to 2023
$4.2M
Spatially Resolved Transcriptomics Enabled by Ultrabright Pdot Probes for Interrogation of Complex TissuesR01MH115767 · NIMH · UNIVERSITY OF WASHINGTON · PI CHIU, DANIEL T, VAUGHAN, JOSHUA · 2017 to 2021
$3.7M
Peripheral Territory Establishment By Zebrafish Somatosensory NeuronsR01AR064582 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAGASTI, ALVARO · 2014 to 2024
$3.6M
Regulation of neuronal morphogenesis and remodeling by the skinK99HD086271 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RASMUSSEN, JEFFREY PHILIP · 2016 to 2017
$247k
Eunice Kennedy Shriver National Institute of Child Health and Human Development NICHD K99 HD086271Japan Society for the Promotion of Science Long term fellowshipNEI NIH HHS NEI P30EY001730NEI NIH HHS P30 EY001730NIAMS NIH HHS NIAMS R01 AR064582NIAMS NIH HHS R01 AR064582NICHD NIH HHS K99 HD086271NIH HHS P40 OD018537NIMH NIH HHS NIMH R01 MH115767NIMH NIH HHS R01 MH115767NINDS NIH HHS NINDS R01 NS076614NINDS NIH HHS R01 NS076614University of Washington WRF-Hall fellowship
6 · The paper itself

Abstract

Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell. Vertebrate and invertebrate epidermal cells ensheath peripheral arbors of somatosensory neurons, including nociceptors, yet the developmental origins and functional roles of this ensheathment are largely unknown. Here, we describe an evolutionarily conserved morphogenetic mechanism for epidermal ensheathment of somatosensory neurites. We found that somatosensory neurons in

Indexed as

MorphogenesisAnimalsDrosophilaEpidermal CellsEpidermisNociceptorsZebrafishD. melanogasterDrosophilaensheathmentepidermisneurosciencenociceptionsomatosensory neuronzebrafish

Identifiers

PMID30855229
PMCPMC6450671
OpenAlexW2950847951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.