Evidence map›Paper›PMID 30855209›Full record

ArticleNucleic acid therapeutics2019

Optimization of a 40-mer Antimyelin DNA Aptamer Identifies a 20-mer with Enhanced Properties for Potential Multiple Sclerosis Therapy.

Brandon Wilbanks, John Smestad, Robin M Heider, Arthur E Warrington, Moses Rodriguez, L James Maher

Open access · hybridAbstract read
In one paragraph

Article in Nucleic acid therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Application of aptamers in regenerative medicine.Frontiers in bioengineering and biotechnology · 2022
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Using Aptamers as a Novel Method for Determining GnRH/LH Pulsatility.International journal of molecular sciences · 2020
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brandon Wilbanks1 Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
John Smestad1 Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Robin M Heider1 Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Arthur E Warrington3 Department of Neurology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Moses Rodriguez3 Department of Neurology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
L James Maher1 Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.
Mayo Clinic · US

Funding

Medical Scientist Traning Program at Mayo ClinicT32GM065841 · NIGMS · MAYO CLINIC ROCHESTER · PI KAUFMANN, SCOTT H, SCHIMMENTI, LISA A · 2003 to 2022
$5.8M
Understanding succinate-induced global transcriptional and epigenetic reprogramming and identifying unique vulnerabilities intrinsic to SDH-deficient cellsF30CA220660 · NCI · MAYO CLINIC ROCHESTER · PI SMESTAD, JOHN ANDREW · 2017 to 2020
$187k
NCI NIH HHS F30 CA220660NIGMS NIH HHS T32 GM065841
6 · The paper itself

Abstract

We previously reported the

Indexed as

AnimalsAptamers, NucleotideCircular DichroismG-QuadruplexesHumansMiceMultiple SclerosisMyelin SheathOligodendrogliomaProtein BindingSELEX Aptamer TechniqueStreptavidinAptamers, NucleotideLJM-3064StreptavidinaptamerconjugateG-quadruplexmultiple sclerosismyelin

Identifiers

PMID30855209
PMCPMC6555174
OpenAlexW2921342798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.