Evidence map›Paper›PMID 30855200›Full record

ArticleJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics2019

GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure.

Tatsuo Itakura, Andrew Webster, Shravan K Chintala, Yuchen Wang, Jose M Gonzalez, J C Tan, Janice A Vranka, Ted Acott, Cheryl Mae Craft, Maria E Sibug Saber and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Osteocalcin and GPR158: linking bone and brain function.Frontiers in cell and developmental biology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Tatsuo Itakura1 USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.
Andrew Webster1 USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.
Shravan K Chintala1 USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.
Yuchen Wang2 Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida.
Jose M Gonzalez3 Doheny Eye Institute and Department of Ophthalmology, University of California Los Angeles, Los Angeles, California.
J C Tan3 Doheny Eye Institute and Department of Ophthalmology, University of California Los Angeles, Los Angeles, California.
Janice A Vranka4 Casey Eye Institute, Oregon Health and Science University, Portland, Oregon.
Ted Acott4 Casey Eye Institute, Oregon Health and Science University, Portland, Oregon.
Cheryl Mae Craft5 USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.
Maria E Sibug Saber7 Department of Pathology, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.
Shinwu Jeong8 USC Institute for Genetic Medicine, Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.
W Daniel Stamer9 Department of Ophthalmology, Duke University, Durham, North Carolina.
Kirill A Martemyanov2 Department of Neuroscience, The Scripps Research Institute, Jupiter, Florida.
M Elizabeth Fini1 USC Institute for Genetic Medicine, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.
University of Southern California · USDoheny Eye Institute · USOregon Health & Science University · USScripps Research Institute · USDuke University · USSouthern California Eye Institute · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Regulation of Signaling in the Retina by RGS ProteinsR01EY018139 · NEI · UNIVERSITY OF MINNESOTA · PI MARTEMYANOV, KIRILL A. · 2007 to 2025
$8.9M
Orphan Receptors in Regulation of Neuronal G Protein SignalingR01MH105482 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kirill A. Martemyanov · 2015 to 2026
$6.1M
Molecular Basis of Photoreceptor WiringR01EY028033 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Kirill A. Martemyanov, Alapakkam P Sampath · 2017 to 2026
$4.6M
Molecular Mechanisms of Outflow Segmentation and Intraocular Pressure HomeostasisR01EY025721 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ACOTT, TED S · 2015 to 2022
$2.8M
Discovery Approach to Ocular HypertensionR01EY027315 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINI, M ELIZABETH, GAO, XIAOYI RAYMOND · 2017 to 2020
$2.4M
Mechanotransduction in Aqueous Outflow Regulation and Open Angle GlaucomaR01EY026048 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ACOTT, TED S, RAGHUNATHAN, VIJAYKRISHNA · 2018 to 2021
$1.5M
Molecular Basis of RGS Protein Function in the StriatumK02DA026405 · NIDA · UNIVERSITY OF MINNESOTA · PI MARTEMYANOV, KIRILL A. · 2009 to 2019
$1.2M
Fibrillin-1 and TGFB2 Abnormality Models POAG Pathogenesis and TreatmentR01EY026935 · NEI · SIGHTGENE, INC. · PI TAN, CHEE HIAN · 2017 to 2019
$1.2M
NEI NIH HHS R01 EY018139NEI NIH HHS R01 EY025721NEI NIH HHS R01 EY026048NEI NIH HHS R01 EY026935NEI NIH HHS R01 EY027315NEI NIH HHS R01 EY028033NIDA NIH HHS K02 DA026405NIDDK NIH HHS P30 DK041301NIMH NIH HHS R01 MH105482
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

HomeostasisIntraocular PressureAnimalsCells, CulturedCell SurvivalDoxycyclineElectroretinographyEyeHumansMiceMice, Inbred C57BLMice, KnockoutRabbitsReceptors, G-Protein-CoupledDoxycyclineGPR158 protein, humanReceptors, G-Protein-CoupledcAMPG-protein-coupled receptorhomeostasisintraocular pressureretinatrabecular meshwork

Identifiers

PMID30855200
PMCPMC6533807
OpenAlexW2922104355

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.