ArticleAnalytical chemistry2019
Clinical-Scale Batch-Mode Production of Hyperpolarized Propane Gas for MRI.
Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Parahydrogen-Hyperpolarized Propane-The journal of physical chemistry. A · 2025Article
- Developing Hyperpolarized Butane Gas for Ventilation Lung Imaging.Chemical & biomedical imaging · 2024Article
- Toward Lung Ventilation Imaging Using Hyperpolarized Diethyl Ether Gas Contrast Agent.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Ultra-Low-Cost Disposable Hand-Held Clinical-Scale Propane Gas Hyperpolarizer for Pulmonary Magnetic Resonance Imaging Sensing.ACS sensors · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Mechanistic Insights into Molecular Crystalline Organometallic Heterogeneous Catalysis through Parahydrogen-Based Nuclear Magnetic Resonance Studies.Journal of the American Chemical Society · 2023Article
- Recent advances in the application of parahydrogen in catalysis and biochemistry.RSC advances · 2022Review
- Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques.Analytical chemistry · 2022Article
- Clinical-Scale Production of Nearly Pure (>98.5%) Parahydrogen and Quantification by Benchtop NMR Spectroscopy.Analytical chemistry · 2021Article
- Low-Flammable Parahydrogen-Polarized MRI Contrast Agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Heterogeneous Parahydrogen-Induced Polarization of Diethyl Ether for Magnetic Resonance Imaging Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Pd-based bimetallic catalysts for parahydrogen-induced polarization in heterogeneous hydrogenations.Magnetic resonance (Gottingen, Germany) · 2021Article
- Parahydrogen-Induced Polarization of Diethyl Ether Anesthetic.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Parahydrogen-Induced Hyperpolarization of Gases.Angewandte Chemie (International ed. in English) · 2020Review
- Recent Advances in Chemical Biology Using Benzophenones and Diazirines as Radical Precursors.Molecules (Basel, Switzerland) · 2020Review
- Relaxation Dynamics of Nuclear Long-Lived Spin States in Propane and Propane-dThe journal of physical chemistry. C, Nanomaterials and interfaces · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
NMR spectroscopy and imaging (MRI) are two of the most important methods to study structure, function, and dynamics from atom to organism scale. NMR approaches often suffer from an insufficient sensitivity, which, however, can be transiently boosted using hyperpolarization techniques. One of these techniques is parahydrogen-induced polarization, which has been used to produce catalyst-free hyperpolarized propane gas with proton polarization that is 3 orders of magnitude greater than equilibrium thermal polarization at a 1.5 T field of a clinical MRI scanner. Here we show that more than 0.3 L of hyperpolarized propane gas can be produced in 2 s. This production rate is more than an order of magnitude greater than that demonstrated previously, and the reported production rate is comparable to that employed for in-human MRI using HP noble gas (e.g.,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.