ArticlePsychological medicine2020
Insulin resistance and obesity, and their association with depression in relatively young people: findings from a large UK birth cohort.
Article in Psychological medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Longitudinal association between cardiovascular risk factors and depression in young people: a systematic review and meta-analysis of cohort studies.Psychological medicine · 2023Pooled it
- Trial
- Effects of Plant Polyphenols on Obesity-Induced Inflammatory Depression: A Review.International journal of molecular sciences · 2026Review
- Depression meets obesity: Co-occurrence patterns, temporal trends and socioeconomic correlates across 199 countries and territories.General psychiatry · 2026Article
- Association between glycemic control, mental problems and nutrition in individuals with type 1 and type 2 diabetes mellitus in primary care settings.BMC public health · 2026Article
- Insulin resistance and the risk of incident depression: the role of age, glycemic status, and adiposity in a prospective cohort study.The Lancet regional health. Western Pacific · 2025Article
- Childhood insulin resistance and neural stem cell dysfunction in psychiatric disorders: Role ofWorld journal of stem cells · 2025Review
- The Association Between Depression and Antidiabetic Treatments in Type 2 Diabetes Patients with Both Good and Poor Glycemic Control.Journal of clinical medicine · 2025Article
- Mediating effect of pro-inflammatory cytokines in the association between depression, anxiety, and cardiometabolic disorders in an ethnically diverse middle-aged and older population.medRxiv : the preprint server for health sciences · 2025Article
- Gut-brain axis as a bridge in obesity and depression: Mechanistic exploration and therapeutic prospects.World journal of psychiatry · 2025Article
- Association of mental health in childhood, adolescence and young adulthood with cardiovascular risk factors and carotid remodeling below age 30 - results from the KiGGS cohort study.European journal of epidemiology · 2025Article
- Lipid metabolic dysregulation-induced neuroinflammation in the pathophysiology of major depressive disorder.Frontiers in immunology · 2025Review
- Association between hypertriglyceridemic-waist phenotype and circadian syndrome risk: a longitudinal cohort study.Hormones (Athens, Greece) · 2023Article
- Cross-sectional and longitudinal associations between cardiometabolic measures and clinical stage in young people accessing early intervention mental health services.Early intervention in psychiatry · 2023Article
- The association between dietary inflammation index and depression.Frontiers in psychiatry · 2023Article
- The Relationship Between Obesity and Depression Is Partly Dependent on Metabolic Health Status: A Nationwide Inpatient Sample Database Study.Frontiers in endocrinology · 2022Article
- Association between Subjective Body Image, Body Mass Index and Psychological Symptoms in Chinese Adolescents: A Nationwide Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2021Article
- Bibliometrics Analysis of the Research Status and Trends of the Association Between Depression and Insulin From 2010 to 2020.Frontiers in psychiatry · 2021Review
- Cardiometabolic risk in young adults with depression and evidence of inflammation: A birth cohort study.Psychoneuroendocrinology · 2020Article
- Potential role of insulin on the pathogenesis of depression.Cell proliferation · 2020Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundDepression frequently co-occurs with disorders of glucose and insulin homeostasis (DGIH) and obesity. Low-grade systemic inflammation and lifestyle factors in childhood may predispose to DGIH, obesity and depression. We aim to investigate the cross-sectional and longitudinal associations among DGIH, obesity and depression, and to examine the effect of demographics, lifestyle factors and antecedent low-grade inflammation on such associations in young people.
methodsUsing the Avon Longitudinal Study of Parents and Children birth cohort, we used regression analyses to examine: (1) cross-sectional and (2) longitudinal associations between measures of DGIH [insulin resistance (IR); impaired glucose tolerance] and body mass index (BMI) at ages 9 and 18 years, and depression (depressive symptoms and depressive episode) at age 18 years and (3) whether sociodemographics, lifestyle factors or inflammation [interleukin-6 (IL-6) at age 9 years] confounded any such associations.
resultsWe included 3208 participants. At age 18 years, IR and BMI were positively associated with depression. These associations may be explained by sociodemographic and lifestyle factors. There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.
conclusionsYoung people with depression show evidence of DGIH and raised BMI, which may be related to sociodemographic and lifestyle effects such as deprivation, smoking, ethnicity and gender. In future, studies with larger samples are required to confirm this. Preventative strategies for the poorer physical health outcomes associated with depression should focus on malleable lifestyle factors.
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