Evidence map›Paper›PMID 30854885›Full record

Trial reportJournal of diabetes science and technology2019

Insulin-Based Infusion System: Advancing the Development.

Nasseh Hashemi, Tim Valk, Kim Houlind, Niels Ejskjaer

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of diabetes science and technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01291719 (Insulin Balanced Infusion System Control of Glucose), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01291719 phase1 / phase2active not recruitingnot on this map

Insulin Balanced Infusion System Control of Glucose

TypeinterventionalSponsorAdmetsys CorporationRan2008 to 2026Enrolled40ConditionsHyperglycemia, DiabetesArmsglucose and insulin infusions
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nasseh Hashemi1 School of Medicine and Health, Aalborg University, Aalborg, Denmark.ORCID 0000-0001-9775-2919
Tim Valk3 Admetsys Research Center, Orlando, FL, USA.
Kim Houlind4 Department of Vascular Surgery, Kolding Hospital, Kolding, Denmark.
Niels Ejskjaer2 Steno Diabetes Center North Jutland, Aalborg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDeviations in glucose control in critical care have been shown to increase mortality and morbidity. However, optimal glucose control through present technologies has shown to be a challenge. The insulin balanced infusion system (IBIS) is a new and emerging technology.

methodsThe closed loop system was tested in a stress trial to evaluate glucose stability in response to various conditions in nonrandomized people with type 1 diabetes mellitus (n=12). The prototype used in this trial was based on intermittent capillary measurements.

resultsInduced stresses in the study using unpredicted stimuli of intravenous or oral glucose and intravenous insulin boluses, was contained with glucose remaining in target 43.8% of the time. Mean increase in glucose concentration after glucose load was 17.4 mg/dl; after insulin bolus, no hypoglycemia (blood glucose less than 70 mg/dl) occurred.

conclusionThe use of IBIS proved safe and feasible under a wide range of conditions. The sensing and stress response of the IBIS demonstrated noticeable features.

Indexed as

Insulin Infusion SystemsAdultBlood GlucoseDiabetes Mellitus, Type 1FemaleHumansHypoglycemic AgentsInsulinMaleMiddle AgedBlood GlucoseHypoglycemic AgentsInsulinautomated glucose monitoringclosed loop glucose controlcritical care glucose controlstress trial

Identifiers

PMID30854885
PMCPMC6955452

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.