ArticleHepatology (Baltimore, Md.)2019
Genome-wide Association Studies of Specific Antinuclear Autoantibody Subphenotypes in Primary Biliary Cholangitis.
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Article in Hepatology (Baltimore, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22citing papers in PubMed, 1 pooled it
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The Genomics/Genetics of Primary Biliary Cholangitis: The Case for a Functional SNP rs10893900 in ETS1/FLI1 and Review of the Literature.Clinical reviews in allergy & immunology · 2025Pooled it
- Dysregulation of apolipoprotein o reprograms CCR7iScience · 2025Article
- Depressive symptom as a risk factor for cirrhosis in patients with primary biliary cholangitis: Analysis based on Lasso-logistic regression and decision tree models.Brain and behavior · 2024Article
- Biliary fibrosis is an important but neglected pathological feature in hepatobiliary disorders: from molecular mechanisms to clinical implications.Medical review (2021) · 2024Review
- Autoantibodes to GP210 are a metric for UDCA responses in primary biliary cholangitis.Journal of translational autoimmunity · 2024Article
- Association of CCR6 functional polymorphisms with Primary Biliary Cholangitis.Journal of translational autoimmunity · 2024Article
- ChIP-seq analysis found IL21R, a target gene of GTF2I-the susceptibility gene for primary biliary cholangitis in Chinese Han.Hepatology international · 2024Article
- Role of autoantibodies in the clinical management of primary biliary cholangitis.World journal of gastroenterology · 2023Review
- A large-scale plasma proteome Mendelian randomization study identifies novel causal plasma proteins related to primary biliary cholangitis.Frontiers in immunology · 2023Article
- Article
- Diagnostic and Clinical Value of Specific Autoantibodies against Kelch-like 12 Peptide and Nuclear Envelope Proteins in Patients with Primary Biliary Cholangitis.Biomedicines · 2022Article
- Human Leukocyte Antigen Association Study Reveals DRB1*04:02 Effects Additional to DRB1*07:01 in Anti-LGI1 Encephalitis.Neurology(R) neuroimmunology & neuroinflammation · 2022Article
- APASL clinical practice guidance: the diagnosis and management of patients with primary biliary cholangitis.Hepatology international · 2022Article
- New insights on the role of human leukocyte antigen complex in primary biliary cholangitis.Frontiers in immunology · 2022Review
- Concentration of Serum Matrix Metalloproteinase-3 in Patients With Primary Biliary Cholangitis.Frontiers in immunology · 2022Article
- Peroxisome Proliferator-Activated Receptors Regulate Hepatic Immunity and Assist in the Treatment of Primary Biliary Cholangitis.Frontiers in immunology · 2022Review
- Autoantibodies - enemies, and/or potential allies?Frontiers in immunology · 2022Review
- Article
- Clinical impact of antibodies to Sp100 on a bacterial infection in patients with primary biliary cholangitis.Journal of clinical laboratory analysis · 2021Article
- Analysis of Autoantibodies against Promyelocytic Leukemia Nuclear Body Components and Biochemical Parameters in Sera of Patients with Primary Biliary Cholangitis.Diagnostics (Basel, Switzerland) · 2021Article
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Authors and funding
51 authors at 19 institutions in 2 countries.
Chan WangKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.ORCID 0000-0002-6198-773X
Xiaodong ZhengDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, and Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China & Key Laboratory of Major Autoimmune Diseases, Anhui Province, Hefei, China.
Peng JiangKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Ruqi TangDepartment of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China.
Yuhua GongDepartment of Laboratory Medicine, The Third People's Hospital of Zhenjiang, Zhenjiang, Jiangsu, China.
Yaping DaiDepartment of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu, China.
Lan WangDepartment of Laboratory Medicine, The 81st Hospital of PLA, Nanjing, Jiangsu, China.
Ping XuDepartment of Laboratory Medicine, The Fifth People's Hospital of Suzhou, Soochow University, Suzhou, Jiangsu, China.
Wenjuan SunKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Lu WangKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Chongxu HanDepartment of Laboratory Medicine, Subei People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China.
Yuzhang JiangDepartment of Laboratory Medicine, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, China.
Yiran WeiDepartment of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China.
Kui ZhangDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Jian WuDepartment of Rheumatology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Youlin ShaoDepartment of Hepatology, The Third People's Hospital of Changzhou, Changzhou, Jiangsu, China.
Yueqiu GaoDepartment of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jianjiang YuDepartment of Laboratory Medicine, Jiangyin People's Hospital, Southeast University, Jiangyin, Jiangsu, China.
Zhigang HuDepartment of Laboratory Medicine, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu, China.
Zhidong ZangDepartment of Hepatology, The Second Hospital of Nanjing, Southeast University, Nanjing, Jiangsu, China.
Yi ZhaoDepartment of Gastrointestinal Endoscopy, Eastern Hepatobiliary Surgery Hospital, Shanghai, China.
Xudong WuDepartment of Gastroenterology, Yancheng First People's Hospital, Yancheng, Jiangsu, China.
Na DaiDepartment of Gastroenterology, Jiangsu University Affiliated Kunshan Hospital, Kunshan, Jiangsu, China.
Lei LiuDepartment of Gastroenterology, Yixing People's Hospital, Yixin, Jiangsu, China.
Jinshan NieDepartment of Gastroenterology, Taicang First People's Hospital, Soochow University, Taicang, Jiangsu, China.
Bo JiangDepartment of Hepatology, Jingjiang Second People's Hospital, Jingjiang, Jiangsu, China.
Maosong LinDepartment of Gastroenterology, Taizhou People's Hospital, Taizhou, Jiangsu, China.
Li LiDepartment of Laboratory Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China.
You LiDepartment of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China.
Sufang ChenDepartment of Laboratory Medicine, The Fifth People's Hospital of Suzhou, Soochow University, Suzhou, Jiangsu, China.
Lixin ShuKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Fang QiuKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Qiuyuan WuKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Mingming ZhangKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Ru ChenKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Rohil JawedKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Yu ZhangKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Xingjuan ShiKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Zhen ZhuDepartment of Hepatology, The Third People's Hospital of Changzhou, Changzhou, Jiangsu, China.
Hao PeiDepartment of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu, China.
Lihua HuangDepartment of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu, China.
Weifeng ZhaoDepartment of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Ye TianDepartment of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xiang ZhuDepartment of Laboratory Medicine, The Fifth People's Hospital of Suzhou, Soochow University, Suzhou, Jiangsu, China.
Hong QiuDepartment of Laboratory Medicine, The 81st Hospital of PLA, Nanjing, Jiangsu, China.
M Eric GershwinDivision of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA.
Weichang ChenDepartment of Gastroenterology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Michael F SeldinDepartment of Biochemistry and Molecular Medicine, University of California at Davis School of Medicine, Davis, CA.
Xiangdong LiuKey Laboratory of Developmental Genes and Human Diseases, Institute of Life Sciences, Southeast University, Nanjing, Jiangsu, China.
Liangdan SunDepartment of Dermatology, The First Affiliated Hospital of Anhui Medical University, and Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China & Key Laboratory of Major Autoimmune Diseases, Anhui Province, Hefei, China.
Xiong MaDepartment of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai, China.
Southeast University · CNSoochow University · CNShanghai Jiao Tong University · CN81th Hospital of PLA · CNJiangsu University · CNAnhui Medical University · CNChangzhou Third People's Hospital · CNNantong University · CNUniversity of California, Davis · USHuaian First People’s Hospital · CNJiangyin People's Hospital · CNNanjing Drum Tower Hospital · CNNanjing Second Hospital · CNSecond Military Medical University · CNShanghai University of Traditional Chinese Medicine · CNWuxi People's Hospital · CNXian Yang Central Hospital · CNYangzhou University · CNZhongda Hospital Southeast University · CN
Funding
Government of Jiangsu Province BE2017713Government of Jiangsu Province BL2018657National Natural Science Foundation of China 81570469National Natural Science Foundation of China 81620108002National Natural Science Foundation of China 81770381National Natural Science Foundation of China 81771732National Natural Science Foundation of China 81830016National Natural Science Foundation of China 81870397
Abstract
Anti-nuclear antibodies to speckled 100 kDa (sp100) and glycoprotein 210 (gp210) are specific serologic markers of primary biliary cholangitis (PBC) of uncertain/controversial clinical or prognostic significance. To study the genetic determinants associated with sp100 and gp210 autoantibody subphenotypes, we performed a genome-wide association analysis of 930 PBC cases based on their autoantibody status, followed by a replication study in 1,252 PBC cases. We confirmed single-nucleotide polymorphisms rs492899 (P = 3.27 × 10
Indexed as
AgedAntibodies, AntinuclearAntigens, NuclearAutoantigensFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLiver Cirrhosis, BiliaryMaleMiddle AgedAntibodies, AntinuclearAntigens, NuclearAutoantigensSP100 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.