ArticleEquine veterinary journal2019
Effect of different doses of inhaled ciclesonide on lung function, clinical signs related to airflow limitation and serum cortisol levels in horses with experimentally induced mild to severe airway obstruction.
Article in Equine veterinary journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The trial behind it
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Randomized study of the effects of testosterone administration on severity of asthma in horses.Journal of veterinary internal medicine · 2026Article
- Steamed hay for the prevention of severe equine asthma exacerbations.Equine veterinary journal · 2026Article
- An in-hospital clinical trial assessing nebulized lidocaine compared to saline for treatment of asthma in horses.Journal of veterinary internal medicine · 2026Article
- Obesity-Associated Metabolomic and Functional Reprogramming in Neutrophils from Horses with Asthma.Animals : an open access journal from MDPI · 2025Article
- Differences in pulmonary function measured by oscillometry between horses with mild-moderate equine asthma and healthy controls.Equine veterinary journal · 2025Article
- Steamed hay and alfalfa pellets for the management of severe equine asthma.Equine veterinary journal · 2025Article
- Article
- Association between equine asthma and fungal elements in the tracheal wash: An environment-matched case-control study.PloS one · 2024Article
- Airway Hyperresponsiveness, but Not Bronchoalveolar Inflammatory Cytokines Profiles, Is Modified at the Subclinical Onset of Severe Equine Asthma.Animals : an open access journal from MDPI · 2023Article
- Co-Occurrence of Severe Equine Asthma and Palatal Disorders in Privately Owned Pleasure Horses.Animals : an open access journal from MDPI · 2023Article
- Review
- Protein microarray allergen profiling in bronchoalveolar lavage fluid and serum of horses with asthma.Journal of veterinary internal medicine · 2023Article
- Article
- Inhalative Nanoparticulate CpG Immunotherapy in Severe Equine Asthma: An Innovative Therapeutic Concept and Potential Animal Model for Human Asthma Treatment.Animals : an open access journal from MDPI · 2022Review
- A CONSORT-guided, randomized, double-blind, controlled pilot clinical trial of inhaled lidocaine for the treatment of equine asthma.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Initial investigation of molecular phenotypes of airway mast cells and cytokine profiles in equine asthma.Frontiers in veterinary science · 2022Article
- Single-cell gene expression analysis of cryopreserved equine bronchoalveolar cells.Frontiers in immunology · 2022Article
- Neutrophil Extracellular Traps Are Found in Bronchoalveolar Lavage Fluids of Horses With Severe Asthma and Correlate With Asthma Severity.Frontiers in immunology · 2022Article
- Inhaled ciclesonide is efficacious and well tolerated in the treatment of severe equine asthma in a large prospective European clinical trial.Equine veterinary journal · 2021Article
- Glucocorticoid treatment in horses with asthma: A narrative review.Journal of veterinary internal medicine · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundInhaled corticosteroids are effective for the treatment of equine asthma but they induce cortisol suppression with potential side effects.
objectivesTo study the efficacy of ciclesonide, an inhaled corticosteroid with an improved safety profile, on lung function, clinical signs related to airway obstruction, and serum cortisol levels in asthmatic horses exposed to a mouldy hay challenge. STUDY
designCross-over placebo controlled, blinded, randomised experiment.
methodsSixteen horses were enrolled in three subsequent dose-titration studies (8 horses/study) to investigate the effects of inhaled ciclesonide administered for 2 weeks at doses ranging from 450 to 2700 μg twice daily or 3712.5 μg once daily. Systemic dexamethasone (0.066 mg/kg per os) was our positive control. A placebo group was also studied. Lung function and clinical scores were blindly performed before and after 7 and 14 days of treatment. Serum cortisol was measured before and after 3, 5, 7, 10, 14 days of treatment as well as 3 and 7 days post treatment.
resultsAfter 7 days, dexamethasone induced a significant reduction in pulmonary resistance (from 2.5 ± 0.6 at day 0 to 1.1 ± 0.7 cm H MAIN LIMITATIONS: Experimentally induced asthma exacerbations in horses might respond differently to treatment than naturally occurring exacerbations.
conclusionsInhaled ciclesonide is an effective treatment for horses with equine asthma. Serum cortisol was unaffected by treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.