Evidence map›Paper›PMID 30854637›Full record

ArticleBritish journal of haematology2019

Haemolysis in sickle cell anaemia: effects of polymorphisms in α-globin gene regulatory elements.

Jacqueline N Milton, Elmutaz M Shaikho, Martin H Steinberg

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Effects of Senegal haplotype (International journal of biochemistry and molecular biology · 2022
    Article
  3. Sickle cell disease in the era of precision medicine: looking to the future.Expert review of precision medicine and drug development · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jacqueline N MiltonDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Elmutaz M ShaikhoDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Martin H SteinbergDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.ORCID 0000-0001-8800-8020
Boston University · US

Funding

Genetic Modulation of Sickle Cell DiseaseR01HL068970 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2001 to 2010
$7.0M
Genome-Wide Association Studies in Sickle Cell Anemia and in CentenariansR01HL087681 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2007 to 2010
$6.0M
RESEARCH TRAINING IN BLOOD DISEASES AND RESOURCEST32HL007501 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LERNER, ADAM, STEINBERG, MARTIN H. · 1985 to 2018
$5.4M
Genetic Diversity of Sickle Cell AnemiaRC2HL101212 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEINBERG, MARTIN H. · 2009 to 2010
$3.0M
Mechanisms of cis-acting HbF regulation in sickle cell anemiaR01HL133350 · NHLBI · BOSTON MEDICAL CENTER · PI MURPHY, GEORGE J, STEINBERG, MARTIN H. · 2017 to 2020
$1.7M
NHLBI NIH HHS R01 HL068970NHLBI NIH HHS R01 HL087681NHLBI NIH HHS R01 HL133350NHLBI NIH HHS RC2 HL101212NHLBI NIH HHS T32 HL007501
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpha-GlobinsAnemia, HemolyticAnemia, Sickle Cellbeta-ThalassemiaDown-RegulationHemoglobin, SickleHemolysisHumansPolymorphism, GeneticUp-Regulationalpha-GlobinsHemoglobin, Sickleglobin gene regulationsickle cell anaemiasickle cell traitα-thalassaemia

Identifiers

PMID30854637
PMCPMC6606385
OpenAlexW2921999325

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.