ReviewInternational journal of implant dentistry2019
General review of titanium toxicity.
Review in International journal of implant dentistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
139 citing papers in PubMed, 3 syntheses or guidelines pooled it, 387 citations in OpenAlex.
- Patient-reported outcomes of zirconia dental implants: a systematic review and future directions.Journal of patient-reported outcomes · 2025Pooled it
- Do implants made of polyetheretherketone and its composites have reduced stress shielding effects compared to other dental implant materials? A systematic review.Evidence-based dentistry · 2023Pooled it
- Diagnostic tests for titanium hypersensitivity in implant dentistry: a systematic review of the literature.International journal of implant dentistry · 2022Pooled it
- Metal-Free Custom-Made Zirconia Implants-A Prospective 5-Year Follow-Up Single-Arm Clinical Trial.Clinical implant dentistry and related research · 2025Trial
- Titanium and Other Metal Hypersensitivity Diagnosed by MELISA® Test: Follow-Up Study.BioMed research international · 2021Trial
- Assessment of ion release, cytotoxicity, and potential systemic toxicity of titanium dental alloy.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- Evaluation of a Sol-Gel Zirconia-Silver Coating for Titanium Implants: Assessing Biocompatibility, Osseointegration, and Enhanced Short-Term Antibacterial Efficacy.Annals of biomedical engineering · 2026Article
- Evaluation of surface roughness of titanium implants on human fibroblast cells.Scientific reports · 2026Article
- Article
- Mining Activities Have Exposed Individuals of an Indigenous Tribe in Brazil to Toxic and Potentially Toxic Elements.Journal of racial and ethnic health disparities · 2026Article
- Influence of Framework Material on Biomechanical Performance of an All-on-4 Prosthesis Supported by Bendable Monoblock Implants.Bioengineering (Basel, Switzerland) · 2026Article
- The use of minerals, plants and burnt materials in ancient medicine: Approaches to working recipes in John the Physician'sProceedings of the Geologists' Association. Geologists' Association · 2026Article
- Peri-implantitis as a potential risk factor for peri-implant oral malignancy.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2026Review
- Allergic Reaction to Titanium Alloy Osteosynthesis Implants: A Case Report of Three Patients.Life (Basel, Switzerland) · 2026Article
- Tracing Toxicity: A Scientometric Perspective on Three Decades of Metallic Pollutants Research.Journal of toxicology · 2026Article
- Silicon Nitride Bioceramics with TiC Additives: Excellent Mechanical Properties, Cytocompatibility, and Antibacterial Properties.Journal of functional biomaterials · 2025Article
- Integration of finite element method and artificial intelligence for evaluating PEEK composites in rib cage reconstruction process under impact conditions.Journal of materials science. Materials in medicine · 2025Article
- Release of Titanium Particles After Implantoplasty in the Treatment of Peri-Implantitis: Local and Systemic Implications-An Integrative Systematic Review.Journal of clinical medicine · 2025Review
- Impact of Laser Surface Modification on Zirconia Implants: A Systematic Review of In Vitro Evidence.Cureus · 2025Review
- From Autologous Bone Tissue to Bioengineered Material Solutions in Post-Traumatic Orbital Wall Reconstruction: An Overview.Journal of functional biomaterials · 2025Review
79 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTitanium is a commonly used inert bio-implant material within the medical and dental fields. Although the use of titanium is thought to be safe with a high success rate, in some cases, there are rare reports of problems caused by titanium. In most of these problematic reports, only individual reports are dominant and comprehensive reporting has not been performed. This comprehensive article has been prepared to review the toxicity of titanium materials within the medical and dental fields.
methodsWe used online searching tools including MEDLINE (PubMed), Embase, Cochrane Library, and Google Scholar by combining keywords such as "titanium implant toxicity," "titanium implant corrosion," "titanium implant allergy," and "yellow nail syndrome." Recently updated data has been collected and compiled into one of four categories: "the toxicity of titanium," "the toxicity of titanium alloys," "the toxicity of titanium implants," and "diseases related to titanium."
resultsRecent studies with regard to titanium toxicity have been increasing and have now expanded to the medical field in addition to the fields of environmental research and basic science. Problems that may arise in titanium-based dental implants include the generation of titanium and titanium alloy particles and ions deposited into surrounding tissues due to the corrosion and wear of implants, resulting in bone loss due to inflammatory reactions, which may lead to osseointegration failure of the dental implant. These titanium ions and particles are systemically deposited and can lead to toxic reactions in other tissues such as yellow nail syndrome. Additionally, implant failure and allergic reactions can occur due to hypersensitivity reactions. Zirconia implants can be considered as an alternative; however, limitations still exist due to a lack of long-term clinical data.
conclusionsClinicians should pay attention to the use of titanium dental implants and need to be aware of the problems that may arise from the use of titanium implants and should be able to diagnose them, in spite of very rare occurrence. Within the limitation of this study, it was suggested that we should be aware the rare problems of titanium toxicity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.