Evidence map›Paper›PMID 30854513›Full record

ArticleJSM Bioinformatics, genomics and preteomics2018

Long Non-Coding RNA Review and Implications in Lung Diseases.

Michael Groot, Duo Zhang, Yang Jin

Open access · greenAbstract read
In one paragraph

Article in JSM Bioinformatics, genomics and preteomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. A proinflammatory long noncoding RNA Lncenc1 regulates inflammasome activation in macrophage.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  5. Mechanisms Contributing to the Comorbidity of COPD and Lung Cancer.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
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  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael GrootDepartment of Medicine, Boston University Medical Campus, USA.
Duo ZhangDepartment of Medicine, Boston University Medical Campus, USA.
Yang JinDepartment of Medicine, Boston University Medical Campus, USA.
Boston University · US

Funding

Development of the RNA molecule-enriched, cell type-specific exosomesR33AI121644 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JIN, YANG · 2018 to 2020
$1.4M
Mechanistic insights of inflammation and organ failure after trauma or critical illnessR01GM127596 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JIN, YANG · 2018 to 2021
$1.3M
Mechanistic insights into the systemic inflammation and organ failure in sepsisR01GM111313 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI JIN, YANG · 2014 to 2017
$1.3M
Development of the RNA molecule-enriched, cell type-specific exosomesR21AI121644 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JIN, YANG · 2016 to 2017
$444k
Lincenc1 regulates the lipopolysaccharide-induced inflammatory response in macrophagesK99HL141685 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZHANG, DUO · 2018 to 2019
$221k
NHLBI NIH HHS K99 HL141685NIAID NIH HHS R21 AI121644NIAID NIH HHS R33 AI121644NIGMS NIH HHS R01 GM111313NIGMS NIH HHS R01 GM127596
6 · The paper itself

Abstract

Non-coding genes occupy the majority of the human genome and have recently garnered increased attention for their implications in a range of diseases. This review illustrates the current scientific landscape concerning long non-coding RNA biogenesis, regulation, and degradation, as well as their functional roles in lung pathogenesis. LncRNAs share many similar biogenesis and regulatory processes with mRNA, such as capping, polyadenylation, post-transcriptional modifications, and exonuclease degradation. Evidence suggests that these lncRNAs become dysregulated in lung diseases such as Acute Lung Injury, Idiopathic Pulmonary Fibrosis, COPD, Lung Cancer, and Pulmonary Arterial Fiypertension. Some lncRNAs have known functions, but the overwhelming majority requires further research to completely understand.

Indexed as

Acute lung injury, Idiopathic pulmonary fibrosisCOPDLong non-coding RNANon-small cell lung cancerPulmonary arterial hypertension

Identifiers

PMID30854513
PMCPMC6404970
OpenAlexW2991186368

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.