Evidence map›Paper›PMID 30854457›Full record

ArticleTomography (Ann Arbor, Mich.)2019

Explaining Deep Features Using Radiologist-Defined Semantic Features and Traditional Quantitative Features.

Rahul Paul, Matthew Schabath, Yoganand Balagurunathan, Ying Liu, Qian Li, Robert Gillies, Lawrence O Hall, Dmitry B Goldgof

Open access · goldAbstract read
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Artificial intelligence-based MRI radiomics and radiogenomics in glioma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
  5. Review
  6. Radiomics in immuno-oncology.Immuno-oncology technology · 2021
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Rahul PaulDepartment of Computer Science and Engineering, University of South Florida, Tampa, FL.
Matthew SchabathDepartment of Cancer Epidemiology, H. L. Moffitt Cancer Center & Research Institute, Tampa, FL.
Yoganand BalagurunathanDepartment of Cancer Imaging and Metabolism, H. L. Moffitt Cancer Center & Research Institute, Tampa, FL; and.
Ying LiuDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin.
Qian LiDepartment of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin.
Robert GilliesDepartment of Cancer Imaging and Metabolism, H. L. Moffitt Cancer Center & Research Institute, Tampa, FL; and.
Lawrence O HallDepartment of Computer Science and Engineering, University of South Florida, Tampa, FL.
Dmitry B GoldgofDepartment of Computer Science and Engineering, University of South Florida, Tampa, FL.
Moffitt Cancer Center · USUniversity of South Florida · USNational Clinical Research · USTianjin Medical University Cancer Institute and Hospital · CN

Funding

Quantitative Imaging Clinical Validation Center at Moffitt Cancer CenterU01CA200464 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JOHN J HEINE, Matthew B. Schabath · 2016 to 2026
$9.2M
Radiomics of NSCLCU01CA143062 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI GILLIES, ROBERT J., SCHABATH, MATTHEW B. · 2010 to 2020
$5.7M
Cellular, molecular and quantitative imaging analysis of screening-detected lung adenocarcinomaU01CA196405 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MALDONADO, FABIEN · 2015 to 2020
$5.4M
Informatics Tools for Optimized Imaging Biomarkers for Cancer Research&DiscoveryU24CA180927 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KALPATHY-CRAMER, JAYASHREE, ROSEN, BRUCE R · 2014 to 2018
$3.4M
Non-invasive evaluation of indeterminate pulmonary nodulesU01CA186145 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MASSION, PIERRE P. · 2015 to 2019
$2.0M
NCI NIH HHS U01 CA143062NCI NIH HHS U01 CA186145NCI NIH HHS U01 CA196405NCI NIH HHS U01 CA200464NCI NIH HHS U24 CA180927
6 · The paper itself

Abstract

Quantitative features are generated from a tumor phenotype by various data characterization, feature-extraction approaches and have been used successfully as a biomarker. These features give us information about a nodule, for example, nodule size, pixel intensity, histogram-based information, and texture information from wavelets or a convolution kernel. Semantic features, on the other hand, can be generated by an experienced radiologist and consist of the common characteristics of a tumor, for example, location of a tumor, fissure, or pleural wall attachment, presence of fibrosis or emphysema, concave cut on nodule surface. These features have been derived for lung nodules by our group. Semantic features have also shown promise in predicting malignancy. Deep features from images are generally extracted from the last layers before the classification layer of a convolutional neural network (CNN). By training with the use of different types of images, the CNN learns to recognize various patterns and textures. But when we extract deep features, there is no specific naming approach for them, other than denoting them by the feature column number (position of a neuron in a hidden layer). In this study, we tried to relate and explain deep features with respect to traditional quantitative features and semantic features. We discovered that 26 deep features from the Vgg-S neural network and 12 deep features from our trained CNN could be explained by semantic or traditional quantitative features. From this, we concluded that those deep features can have a recognizable definition via semantic or quantitative features.

Indexed as

AlgorithmsDeep LearningHumansLung NeoplasmsNeural Networks, ComputerRadiographic Image Interpretation, Computer-AssistedSemanticsSolitary Pulmonary NoduleTomography, X-Ray ComputedCNNdeep featuresexplainable AIinterpretation of featuresquantitative featuresradiomicssemantic features

Identifiers

PMID30854457
PMCPMC6403047
OpenAlexW2943374613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.