Evidence map›Paper›PMID 30854455›Full record

ArticleTomography (Ann Arbor, Mich.)2019

ePAD: An Image Annotation and Analysis Platform for Quantitative Imaging.

Daniel L Rubin, Mete Ugur Akdogan, Cavit Altindag, Emel Alkim

Abstract read
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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  17. Blockchain in healthcare today · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel L RubinDepartment of Biomedical Data Science, Radiology, and Medicine (Biomedical Informatics Research), Stanford University, Stanford, CA.
Mete Ugur AkdoganDepartment of Biomedical Data Science, Radiology, and Medicine (Biomedical Informatics Research), Stanford University, Stanford, CA.
Cavit AltindagDepartment of Biomedical Data Science, Radiology, and Medicine (Biomedical Informatics Research), Stanford University, Stanford, CA.
Emel AlkimDepartment of Biomedical Data Science, Radiology, and Medicine (Biomedical Informatics Research), Stanford University, Stanford, CA.

Funding

Qualification and Deployment of Imaging Biomarkers of Cancer Treatment ResponseU01CA190214 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2015 to 2020
$3.1M
Computing, Optimizing, and Evaluating Quantitative Cancer Imaging BiomarkersU01CA187947 · NCI · STANFORD UNIVERSITY · PI NAPEL, SANDY A., RUBIN, DANIEL L · 2015 to 2019
$2.9M
Computerized Quantitative Imaging Assessment of Tumor BurdenU01CA142555 · NCI · STANFORD UNIVERSITY · PI RUBIN, DANIEL L · 2010 to 2014
$2.9M
NCI NIH HHS U01 CA142555NCI NIH HHS U01 CA187947NCI NIH HHS U01 CA190214
6 · The paper itself

Abstract

Medical imaging is critical for assessing the response of patients to new cancer therapies. Quantitative lesion assessment on images is time-consuming, and adopting new promising quantitative imaging biomarkers of response in clinical trials is challenging. The electronic Physician Annotation Device (ePAD) is a freely available web-based zero-footprint software application for viewing, annotation, and quantitative analysis of radiology images designed to meet the challenges of quantitative evaluation of cancer lesions. For imaging researchers, ePAD calculates a variety of quantitative imaging biomarkers that they can analyze and compare in ePAD to identify potential candidates as surrogate endpoints in clinical trials. For clinicians, ePAD provides clinical decision support tools for evaluating cancer response through reports summarizing changes in tumor burden based on different imaging biomarkers. As a workflow management and study oversight tool, ePAD lets clinical trial project administrators create worklists for users and oversee the progress of annotations created by research groups. To support interoperability of image annotations, ePAD writes all image annotations and results of quantitative imaging analyses in standardized file formats, and it supports migration of annotations from various propriety formats. ePAD also provides a plugin architecture supporting MATLAB server-side modules in addition to client-side plugins, permitting the community to extend the ePAD platform in various ways for new cancer use cases. We present an overview of ePAD as a platform for medical image annotation and quantitative analysis. We also discuss use cases and collaborations with different groups in the Quantitative Imaging Network and future directions.

Indexed as

AlgorithmsDatabases, FactualData CurationDecision Support Systems, ClinicalHumansImage Interpretation, Computer-AssistedNeoplasmsRadiology Information SystemsSoftware DesignTreatment OutcomeAIM (Annotation and Image Markup)biomarker evaluationDICOM SR (DICOM Structure Report)feature extractionmedical image annotation

Identifiers

PMID30854455
PMCPMC6403025

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.