Evidence map›Paper›PMID 30854443›Full record

Trial reportTomography (Ann Arbor, Mich.)2019

Real-Time Quantitative Assessment of Accuracy and Precision of Blood Volume Derived from DCE-MRI in Individual Patients During a Clinical Trial.

Madhava P Aryal, Choonik Lee, Peter G Hawkins, Christina Chapman, Avraham Eisbruch, Michelle Mierzwa, Yue Cao

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
In one paragraph

Trial report in Tomography (Ann Arbor, Mich.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Randomized Phase II Study of Physiologic MRI-Directed Adaptive Radiation Boost in Poor Prognosis Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Trial
  3. Early HPV ctDNA Kinetics and Imaging Biomarkers Predict Therapeutic Response in p16+ Oropharyngeal Squamous Cell Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Trial
  4. Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia.International journal of radiation oncology, biology, physics · 2021
    Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Madhava P AryalDepartments of Radiation Oncology.
Choonik LeeDepartments of Radiation Oncology.
Peter G HawkinsDepartments of Radiation Oncology.
Christina ChapmanDepartments of Radiation Oncology.
Avraham EisbruchDepartments of Radiation Oncology.
Michelle MierzwaDepartments of Radiation Oncology.
Yue CaoDepartments of Radiation Oncology.

Funding

Functional imaging-directed adaptive therapy of head and neck cancerR01CA184153 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAO, YUE · 2015 to 2019
$2.4M
Quantitative MRI models of HN Cancers for Physiological Adaption of RTU01CA183848 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAO, YUE · 2014 to 2019
$2.0M
NCI NIH HHS R01 CA184153NCI NIH HHS U01 CA183848
6 · The paper itself

Abstract

Accuracy and precision of quantitative imaging (QI) metrics should be assessed in real time in each patient during a clinical trial to support QI-based decision-making. We developed a framework for real-time quantitative assessment of QI metrics and evaluated accuracy and precision of dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI)-derived blood volume (BV) in a clinical trial for head and neck cancers. Patients underwent DCE-MRI before and after 2 weeks of radiation therapy (2wkRT). A mean as a reference value and a repeatability coefficient (RC) of BV values established from

Indexed as

Cerebral Blood VolumeAgedCerebellumContrast MediaDecision Making, Computer-AssistedFemaleHead and Neck NeoplasmsHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeoplasm StagingPrognosisReproducibility of ResultsContrast Mediablood volumedynamic contrast enhanced MRIhead and neck cancerquantitative imagingreal-time assessmentrepeatability

Identifiers

PMID30854443
PMCPMC6403042

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.