Evidence map›Paper›PMID 30854429›Full record

ArticleScience advances2019

A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues.

Ryan M Cassidy, Yungang Lu, Madhavi Jere, Jin-Bin Tian, Yuanzhong Xu, Leandra R Mangieri, Blessing Felix-Okoroji, Jennifer Selever, Yong Xu, Benjamin R Arenkiel and 1 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The Somatostatin Pathway Projected from the Basal Forebrain to the Lateral Habenula Promotes Isoflurane Anesthesia Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Article
  7. GABAMedComm · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Negative Emotions Recruit the Parabrachial Nucleus Efferent to the VTA to Disengage Instrumental Food Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Ryan M CassidyBrown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, UTHealth McGovern Medical School, 7000 Fannin St., Houston, TX 77030, USA.ORCID 0000-0003-4100-0413
Yungang LuBrown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, UTHealth McGovern Medical School, 7000 Fannin St., Houston, TX 77030, USA.ORCID 0000-0001-8949-661X
Madhavi JereVassar College, 124 Raymond Avenue, Poughkeepsie, NY 12604, USA.ORCID 0000-0002-8216-1347
Jin-Bin TianBrown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, UTHealth McGovern Medical School, 7000 Fannin St., Houston, TX 77030, USA.
Yuanzhong XuBrown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, UTHealth McGovern Medical School, 7000 Fannin St., Houston, TX 77030, USA.ORCID 0000-0002-5264-5324
Leandra R MangieriBrown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, UTHealth McGovern Medical School, 7000 Fannin St., Houston, TX 77030, USA.
Blessing Felix-OkorojiRice University, 6100 Main St., Houston, TX 77005-1892, USA.
Jennifer SeleverIntellectual and Developmental Disabilities Research Center, Neuroconnectivity Core, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030, USA.
Benjamin R ArenkielIntellectual and Developmental Disabilities Research Center, Neuroconnectivity Core, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Qingchun TongBrown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, UTHealth McGovern Medical School, 7000 Fannin St., Houston, TX 77030, USA.ORCID 0000-0002-4561-2540
Brown Foundation · USThe University of Texas MD Anderson Cancer Center · USBaylor College of Medicine · USRice University · USVassar College · US

Funding

Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, SAMACO, RODNEY C · 2014 to 2019
$7.8M
R01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4M
Center for Clinical and Translational Sciences (CCTS)TL1TR000369 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$1.9M
Neurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8M
A direct LH to PVH projection for antagonistic regulation of feedingR01DK114279 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2018 to 2021
$1.5M
Targeting hypothalamic steroid receptor co-activator-1 to treat obesityR01DK101379 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2014 to 2017
$1.2M
To deconstruct a hypothalamic neural circuit pathway for feeding and compulsive behaviorsF31DA041703 · NIDA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MANGIERI, LEANDRA · 2016 to 2018
$78k
NCATS NIH HHS TL1 TR000369NICHD NIH HHS U54 HD083092NIDA NIH HHS F31 DA041703NIDDK NIH HHS R01 DK101379NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK114279NIDDK NIH HHS R01 DK117281
6 · The paper itself

Abstract

Animals must consider competing information before deciding to eat: internal signals indicating the desirability of food and external signals indicating the risk involved in eating within a particular environment. The behaviors driven by the former are manifestations of hunger, and the latter, anxiety. The connection between pathologic anxiety and reduced eating in conditions like typical depression and anorexia is well known. Conversely, anti-anxiety drugs such as benzodiazepines increase appetite. Here, we show that GABAergic neurons in the diagonal band of Broca (DBB

Indexed as

CuesEnvironmentFeeding BehaviorNerve NetAnimalsAnxietyBasal ForebrainGABAergic NeuronsHypothalamic Area, LateralMiceSynaptic Transmission

Identifiers

PMID30854429
PMCPMC6402846
OpenAlexW2920701527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.