Evidence map›Paper›PMID 30854315›Full record

ArticleAnnals of cardiothoracic surgery2019

Temporary mechanical circulatory support for refractory heart failure: the German Heart Center Berlin experience.

Gaik Nersesian, Felix Hennig, Marcus Müller, Johanna Mulzer, Dmytro Tsyganenko, Christoph Starck, Tom Gromann, Volkmar Falk, Evgenij Potapov, Felix Schoenrath

Open access · diamondAbstract read
In one paragraph

Article in Annals of cardiothoracic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Temporary extracorporeal life support: single-centre experience with a new concept.Interdisciplinary cardiovascular and thoracic surgery · 2024
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  20. Advanced heart failure with reduced ejection fraction.Proceedings (Baylor University. Medical Center) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gaik NersesianDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Felix HennigDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Marcus MüllerDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Johanna MulzerDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Dmytro TsyganenkoDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Christoph StarckDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Tom GromannDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Volkmar FalkDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Evgenij PotapovDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Felix SchoenrathDepartment of Cardiothoracic and Vascular Surgery, German Heart Center Berlin, Berlin, Germany.
Deutsches Herzzentrum der Charité · DEHumboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTemporary mechanical circulatory support (MCS) offers a valuable option for treatment of refractory heart failure. We present our experience with selected MCS devices in cardiogenic shock of different etiologies.

methodsWe retrospectively studied patients who were treated in our institution between 01/2016 and 07/2018. Patients receiving only veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support were excluded. Left ventricular support patients received Impella; right ventricular support was conducted using Levitronix CentriMag.

resultsThirty-seven patients received an Impella left ventricular assist device (LVAD). Etiology was: acute on chronic ischemic cardiomyopathy (ICMP; n=12), acute myocardial infarction (AMI; n=11), dilated cardiomyopathy (DCMP; n=7) and toxic cardiomyopathy (TCMP; n=2). Two patients presented with postcardiotomy shock and acute myocarditis, respectively. In one case, Takotsubo cardiomyopathy was diagnosed. Impella was used solely in 28 patients (Impella group) with an in-hospital survival of 37%. In nine patients, Impella was used in combination with extracorporeal life support (ECLS) implantation (ECMELLA group)-in-hospital survival was 33%. In the Impella group six patients recovered, six received a long-term VAD and 16 died on device. In the ECMELLA group one patient recovered, three received a long-term VAD and five died. The majority of CentriMag implantations as a right ventricular assist device (RVAD) were necessary after LVAD implantation (n=52); of these patients, 14 recovered, eight received long-term VAD and 30 died. The remaining 17 patients were supported by RVAD due to AMI (n=7); postcardiotomy (n=7); right heart failure after heart transplantation (n=2) and ICMP (n=1). Six of these patients recovered, two required long-term VAD and nine died.

conclusionsSurvival after MCS implantation for left as well as right heart failure in cardiogenic shock remains low, but is superior to that of patients without mechanical support. Short-term MCS remains an option of choice if right, left or biventricular support is needed.

Indexed as

cardiogenic shockCentriMagImpellaMechanical circulatory support (MCS)

Identifiers

PMID30854315
PMCPMC6379195
OpenAlexW2904308857

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.