ReviewAnnals of cardiothoracic surgery2019
Heparin-induced thrombocytopenia during extracorporeal life support: incidence, management and outcomes.
Review in Annals of cardiothoracic surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Low vs standardized dose anticoagulation regimens for extracorporeal membrane oxygenation: A meta-analysis.PloS one · 2021Pooled it
- Prolonged Extracorporeal Membrane Oxygenation Without Systemic Anticoagulation in Sheep.Annals of biomedical engineering · 2026Article
- Anticoagulant effects of nafamostat administered via central venous catheter versus the ECMO circuit in adults receiving ECMO support.Frontiers in cardiovascular medicine · 2026Article
- Alternative Anticoagulation for Patients with Heparin-Induced Thrombocytopenia on ECMO: A Narrative Review.Biomedicines · 2025Review
- Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations.BMC anesthesiology · 2025Article
- A safety comparison of heparin and argatroban anticoagulation in veno-venous extracorporeal membrane oxygenation with a focus on bleeding.Transfusion medicine (Oxford, England) · 2025Observational
- Heparin-induced thrombocytopenia in extracorporeal membrane oxygenation-supported patients: a systematic review and meta-analysis.Thrombosis journal · 2024Article
- The role of extracorporeal membrane oxygenation in the management of heparin-induced thrombocytopenia with total occlusion of a native coronary artery: a case report.Anaesthesiology intensive therapy · 2024Article
- Heparin-Induced Thrombocytopenia in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2023Article
- Anticoagulation Management during Extracorporeal Membrane Oxygenation-A Mini-Review.Medicina (Kaunas, Lithuania) · 2022Review
- Evaluation of clinical outcomes in patients treated with heparin or direct thrombin inhibitors during extracorporeal membrane oxygenation: a systematic review and meta-analysis.Thrombosis journal · 2022Article
- Heparin-induced thrombocytopenia in extra-corporeal membrane oxygenation: epidemiology, outcomes, and diagnostic challenges.Journal of thrombosis and thrombolysis · 2022Article
- New challenges in cardiac intensive care units.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- The complicated relationships of heparin-induced thrombocytopenia and platelet factor 4 antibodies with COVID-19.International journal of laboratory hematology · 2021Review
- Veno-arterial extracorporeal membrane oxygenation: Special reference for use in 'post-cardiotomy cardiogenic shock' - A review with an Indian perspective.Indian journal of thoracic and cardiovascular surgery · 2021Article
- Anticoagulation in ECMO patients: an overview.Indian journal of thoracic and cardiovascular surgery · 2021Review
- Neurocritical Care of Mechanical Circulatory Support Devices.Current neurology and neuroscience reports · 2021Review
- COVID-19 and Extracorporeal Membrane Oxygenation.Advances in experimental medicine and biology · 2021Review
- Observational
- Can Heparin-Coated ECMO Cannulas Induce Thrombocytopenia in COVID-19 Patients?Case reports in immunology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeparin-induced thrombocytopenia (HIT) is a severe antibody-mediated reaction leading to transient prothrombosis. However, its incidence in patients on extracorporeal life support (ECLS) is not well described. The aim of this systematic review was to report the incidence of HIT in patients on ECLS, as well as compare the characteristics and outcomes of HIT in patients undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and veno-venous ECMO (VV-ECMO).
methodsAn electronic search was performed to identify all studies in the English literature examining outcomes of patients with HIT on ECLS. All identified articles were systematically assessed using specific inclusion and exclusion criteria. Random effects meta-analysis as well as univariate analysis was performed.
resultsOf 309 patients from six retrospective studies undergoing ECLS, 83% were suspected, and 17% were confirmed to have HIT. Due to the sparsity of relevant retrospective data regarding patients with confirmed HIT on ECLS, patient-based data was subsequently collected on 28 patients from case reports and case series. Out of these 28 patients, 53.6% and 46.4% of them underwent VA-ECMO and VV-ECMO, respectively. Patients on VA-ECMO had a lower median platelet count nadir (VA-ECMO: 26.0
conclusionsPatients who develop HIT on VA-ECMO are more likely to experience more severe thrombocytopenia and arterial thromboembolism than those on VV-ECMO. Further research in this area and development of standardized protocols for the monitoring, diagnosis and management of HIT in patients on ECLS support are warranted.
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