ArticleCell death discovery2019
Maturation-associated gene expression profiles during normal human bone marrow erythropoiesis.
Article in Cell death discovery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
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- Transcriptomic profiling of peripheral blood cells in HPV-associated carcinoma patients receiving combined valproic acid and avelumab.Molecular oncology · 2024Article
- Germline Variants and Characteristic Features of Hereditary Hematological Malignancy Syndrome.International journal of molecular sciences · 2024Review
- Integrative analysis of PANoptosis-related genes in diabetic retinopathy: machine learning identification and experimental validation.Frontiers in immunology · 2024Article
- Erythroid Cells as Full Participants in the Tumor Microenvironment.International journal of molecular sciences · 2023Review
- Article
- Recent updates of stem cell-based erythropoiesis.Human cell · 2023Review
- Regulation of eIF4E guides a unique translational program to control erythroid maturation.Science advances · 2022Article
- Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1-Mutant Myelodysplastic Syndromes With Ringed Sideroblasts.Blood cancer discovery · 2022Article
- Erythroid lineage-specific lentiviral RNAi vectors suitable for molecular functional studies and therapeutic applications.Scientific reports · 2022Article
- Detection of erythroid progenitors and erythrocytopathies in patients with severe COVID-19 disease.Saudi medical journal · 2022Article
- ATG4A regulates human erythroid maturation and mitochondrial clearance.Blood advances · 2022Article
- Phiclust: a clusterability measure for single-cell transcriptomics reveals phenotypic subpopulations.Genome biology · 2022Article
- The role of erythrocytes and erythroid progenitor cells in tumors.Open life sciences · 2022Review
- Dynamic changes in human single-cell transcriptional signatures during fatal sepsis.Journal of leukocyte biology · 2021Article
- Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications.Blood advances · 2021Article
- Comprehensive transcriptome analysis of erythroid differentiation potential of olive leaf in haematopoietic stem cells.Journal of cellular and molecular medicine · 2021Article
- Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients.Stem cell reports · 2021Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythropoiesis has been extensively studied using in vitro and in vivo animal models. Despite this, there is still limited data about the gene expression profiles (GEP) of primary (ex vivo) normal human bone marrow (BM) erythroid maturation. We investigated the GEP of nucleated red blood cell (NRBC) precursors during normal human BM erythropoiesis. Three maturation-associated populations of NRBC were identified and purified from (fresh) normal human BM by flow cytometry and the GEP of each purified cell population directly analyzed using DNA-oligonucleotide microarrays. Overall, 6569 genes (19% of the genes investigated) were expressed in ≥1 stage of BM erythropoiesis at stable (e.g., genes involved in DNA process, cell signaling, protein organization and hemoglobin production) or variable amounts (e.g., genes related to cell differentiation, apoptosis, metabolism), the latter showing a tendency to either decrease from stage 1 to 3 (genes associated with regulation of erythroid differentiation and survival, e.g.,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.