ReviewInternational journal of biomaterials2019
Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer.
Review in International journal of biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 5 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Effect of Dentin Biomodification on the Survival of Resin Composite Restorations: An Umbrella Review.International dental journal · 2026Pooled it
- HEMA-free versus HEMA-containing adhesive systems: a systematic review.Systematic reviews · 2025Pooled it
- Effect of collagen crosslinkers on sodium hypochlorite treated dentin bond strength: a systematic review and meta-analysis.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Effects of Er: YAG, Er,Cr: YSGG, and Nd: YAG laser irradiation and adhesive systems on the immediate and long-term bond strength of dentin: a systematic review and meta-analysis.Lasers in medical science · 2023Pooled it
- Does the etching strategy influence the bonding of universal adhesive systems to primary teeth? A systematic review and meta-analysis of in vitro studies.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Pooled it
- Clinical performance of the ethanol-wet bonding technique with different adhesive systems in noncarious cervical lesion restorations: a 6-year randomized clinical trial.Clinical oral investigations · 2026Trial
- In Vitro Evaluation of Bond Strength of Adhesive Systems to Dentin and Stability of the Hybrid Layer.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- Effect of Immediate Dentin Sealing on the Bond Strength of Resin Cement to Diabetic Dentin.Biomimetics (Basel, Switzerland) · 2026Article
- In situ formation of Ca-Ag hybrid nanoparticles for multifunctional reconstruction of the resin-dentin interface.Clinical oral investigations · 2026Article
- The Use of Bovine Teeth as an Experimental Substrate in the Evaluation of Shear in Contemporary Adhesive Systems.Polymers · 2026Article
- Adhesive bonding to dentin in aging and diabetes: a scoping review of substrate-related changes and bonding outcomes.BMC oral health · 2026Article
- Nature's Cross-linkers:International journal of clinical pediatric dentistry · 2026Article
- Effects of phytic and tannic acids on dentin bonding, nanoleakage, and micropermeability under wet and dry bonding techniques.Odontology · 2026Article
- Biomodification of dentin collagen with hydroalcoholic propolis extract: Impact on resin-dentin adhesion.European journal of oral sciences · 2026Article
- Effect of ammonia-free silver fluoride application on the resin-dentin interface subjected to an in situ cariogenic challenge.Clinical oral investigations · 2026Article
- Effect of different dentin etching protocols on the immediate microtensile bond strength of two bulk-fill restorative systems in class I cavities.BMC oral health · 2026Article
- Bonding Performance and Interfacial Ultra-Morphology/Nanoleakage of a Modern Self-Curing Bulk-Fill Restorative System: An In Vitro Study.European journal of dentistry · 2026Article
- Age-Related Alterations in SIBLING Proteins and Dentin Micro-Architecture: Morphological and Molecular Associations.Life (Basel, Switzerland) · 2025Article
- Advances in Bioactive Dental Adhesives for Caries Prevention: A State-of-the-Art Review.Journal of functional biomaterials · 2025Review
- Protective role of ellagic acid in the adhesive interface after dental bleaching.Scientific reports · 2025Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have shown that the dentin-resin interface is unstable due to poor infiltration of resin monomers into the demineralized dentin matrix. This phenomenon is related to the incomplete infiltration of the adhesive system into the network of exposed collagen fibrils, mainly due to the difficulty of displacement and subsequent replacement of trapped water between interfibrillar spaces, avoiding adequate hybridization within the network of collagen fibrils. Thus, unprotected fibrils are exposed to undergo denaturation and are susceptible to cyclic fatigue rupture after being subjected to repetitive loads during function. The aqueous inclusions within the hybrid layer serve as a functional medium for the hydrolysis of the resin matrix, giving rise to the activity of esterases and collagenolytic enzymes, such as matrix metalloproteinases, which play a fundamental role in the degradation process of the hybrid layer. Achieving better interdiffusion of the adhesive system in the network of collagen fibrils and the substrate stability in the hybrid layer through different strategies are key events for the interfacial microstructure to adequately function. Hence, it is important to review the factors related to the mechanisms of degradation and stabilization of the hybrid layer to support the implementation of new materials and techniques in the future. The enzymatic degradation of collagen matrix, together with resin leaching, has led to seeking strategies that inhibit the endogenous proteases, cross-linking the denudated collagen fibrils and improving the adhesive penetration removing water from the interface. Some of dentin treatments have yielded promising results and require more research to be validated. A longer durability of adhesive restorations could resolve a variety of clinical problems, such as microleakage, recurrent caries, postoperative sensitivity, and restoration integrity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.