Evidence map›Paper›PMID 30853957›Full record

ReviewFrontiers in immunology2019

Ways Forward for Tolerance-Inducing Cellular Therapies- an AFACTT Perspective.

Anja Ten Brinke, Marc Martinez-Llordella, Nathalie Cools, Catharien M U Hilkens, S Marieke van Ham, Birgit Sawitzki, Edward K Geissler, Giovanna Lombardi, Piotr Trzonkowski, Eva Martinez-Caceres

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Multiple sclerosis: molecular pathogenesis and therapeutic intervention.Signal transduction and targeted therapy · 2025
    Review
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  8. Review
  9. Autologous cell therapy - A new concept to eradicate inhibitors in haemophilia.Haemophilia : the official journal of the World Federation of Hemophilia · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Tolerogenic Dendritic Cell-Based Approaches in Autoimmunity.International journal of molecular sciences · 2021
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 6 countries.

Anja Ten BrinkeDepartment of Immunopathology, Sanquin Research, Amsterdam, Netherlands.
Marc Martinez-LlordellaDepartment of Inflammation Biology, MRC Centre for Transplantation, School of Immunology and Microbial Sciences, Institute of Liver Studies, King's College London, London, United Kingdom.
Nathalie CoolsLaboratory of Experimental Hematology, Faculty of Medicine and Health Sciences, Vaccine and Infectious Disease Institute (Vaxinfectio), University of Antwerp, Antwerp, Belgium.
Catharien M U HilkensInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom.
S Marieke van HamDepartment of Immunopathology, Sanquin Research, Amsterdam, Netherlands.
Birgit SawitzkiCharité-Universitaetsmedizin Berlin, Berlin Institute of Health, Institute for Medical Immunology, Humboldt-Universitaet zu Berlin, Berlin, Germany.
Edward K GeisslerSection of Experimental Surgery, Department of Surgery, University Hospital Regensburg, University of Regensburg, Regensburg, Germany.
Giovanna LombardiDivision of Transplantation Immunology and Mucosal Biology, MRC Centre for Transplantation, Guy's Hospital, King's College London, London, United Kingdom.
Piotr TrzonkowskiDepartment of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland.
Eva Martinez-CaceresDivision of Immunology, Germans Trias i Pujol University Hospital, LCMN, IGTP, Badalona, Spain.
Charité - Universitätsmedizin Berlin · DEGdańsk Medical University · PLGuy's Hospital · GBKing's College London · GBNewcastle University · GBSanquin · NLUniversitat Autònoma de Barcelona · ESUniversity Hospital Regensburg · DEUniversity of Amsterdam · NLUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical studies with cellular therapies using tolerance-inducing cells, such as tolerogenic antigen-presenting cells (tolAPC) and regulatory T cells (Treg) for the prevention of transplant rejection and the treatment of autoimmune diseases have been expanding the last decade. In this perspective, we will summarize the current perspectives of the clinical application of both tolAPC and Treg, and will address future directions and the importance of immunomonitoring in clinical studies that will result in progress in the field.

Indexed as

Cell- and Tissue-Based TherapyImmune ToleranceImmunomodulationAnimalsAntigen-Presenting CellsAutoimmunityBiomarkersClinical Studies as TopicDendritic CellsHumansImmunophenotypingImmunotherapyT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsBiomarkersautoimmunitycell therapyclinicdendritic cellsimmunomonitoringregulatory T cellstolerancetransplantation

Identifiers

PMID30853957
PMCPMC6395407
OpenAlexW2915450228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.