Evidence map›Paper›PMID 30853933›Full record

ReviewFrontiers in neurology2019

Standards in Pupillography.

Carina Kelbsch, Torsten Strasser, Yanjun Chen, Beatrix Feigl, Paul D Gamlin, Randy Kardon, Tobias Peters, Kathryn A Roecklein, Stuart R Steinhauer, Elemer Szabadi and 3 more

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 100 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 2 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 2 syntheses or guidelines pooled it, 190 citations in OpenAlex.

  1. Pooled it
  2. Measurement Methods of Fatigue, Sleepiness, and Sleep Behaviour Aboard Ships: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Does EyeKinetix pupillometry clarify RAPD detection?Documenta ophthalmologica. Advances in ophthalmology · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Comparative analysis of pupillometry in two scheimpflug-based measurement systems.Documenta ophthalmologica. Advances in ophthalmology · 2025
    Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Carina KelbschPupil Research Group, Centre for Ophthalmology, University Hospitals Tübingen, Tübingen, Germany.
Torsten StrasserPupil Research Group, Centre for Ophthalmology, University Hospitals Tübingen, Tübingen, Germany.
Yanjun ChenDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, AL, United States.
Beatrix FeiglInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
Paul D GamlinDepartment of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, AL, United States.
Randy KardonNeuro-Ophthalmology Division, University of Iowa and Iowa City VA Healthcare System, Iowa City, LA, United States.
Tobias PetersPupil Research Group, Centre for Ophthalmology, University Hospitals Tübingen, Tübingen, Germany.
Kathryn A RoeckleinDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, United States.
Stuart R SteinhauerVA Pittsburgh Healthcare System, VISN 4 MIRECC, University Drive C, Pittsburgh, PA, United States.
Elemer SzabadiDevelopmental Psychiatry, University of Nottingham, Nottingham, United Kingdom.
Andrew J ZeleInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.
Helmut WilhelmPupil Research Group, Centre for Ophthalmology, University Hospitals Tübingen, Tübingen, Germany.
Barbara J WilhelmPupil Research Group, Centre for Ophthalmology, University Hospitals Tübingen, Tübingen, Germany.
STZ eyetrial · DEUniversity of Pittsburgh · USIowa City VA Health Care System · USQueensland Eye Institute · AUQueensland University of Technology · AUUniversity of Alabama at Birmingham · USUniversity of Nottingham · GB

Funding

Intrinsically photosensitive retinal ganglion cells and their central projectionsR01EY025555 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DO, MICHAEL TRI HOANG, GAMLIN, PAUL DOUGLAS · 2016 to 2020
$3.9M
COMPONENTS OF PUPILLARY DILATION AND COGNITIONR01MH055762 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STEINHAUER, STUART ROBERT · 1997 to 2010
$2.7M
NEI NIH HHS R01 EY025555NIMH NIH HHS R01 MH055762
6 · The paper itself

Abstract

The number of research groups studying the pupil is increasing, as is the number of publications. Consequently, new standards in pupillography are needed to formalize the methodology including recording conditions, stimulus characteristics, as well as suitable parameters of evaluation. Since the description of intrinsically photosensitive retinal ganglion cells (ipRGCs) there has been an increased interest and broader application of pupillography in ophthalmology as well as other fields including psychology and chronobiology. Color pupillography plays an important role not only in research but also in clinical observational and therapy studies like gene therapy of hereditary retinal degenerations and psychopathology. Stimuli can vary in size, brightness, duration, and wavelength. Stimulus paradigms determine whether rhodopsin-driven rod responses, opsin-driven cone responses, or melanopsin-driven ipRGC responses are primarily elicited. Background illumination, adaptation state, and instruction for the participants will furthermore influence the results. This standard recommends a minimum set of variables to be used for pupillography and specified in the publication methodologies. Initiated at the 32nd International Pupil Colloquium 2017 in Morges, Switzerland, the aim of this manuscript is to outline standards in pupillography based on current knowledge and experience of pupil experts in order to achieve greater comparability of pupillographic studies. Such standards will particularly facilitate the proper application of pupillography by researchers new to the field. First we describe general standards, followed by specific suggestions concerning the demands of different targets of pupil research: the afferent and efferent reflex arc, pharmacology, psychology, sleepiness-related research and animal studies.

Indexed as

analysisapplication of pupillographyclinical standardsparameters of evaluationpupillographypupillometrystimulus characteristics

Identifiers

PMID30853933
PMCPMC6395400
OpenAlexW2912521876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.