ReviewFrontiers in pharmacology2019
Chronic Pain and Chronic Opioid Use After Intensive Care Discharge - Is It Time to Change Practice?
Review in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 44 citations in OpenAlex.
- Strategies for a Rational Use of Opioids in Critical Care Settings.Journal of clinical medicine · 2026Review
- New persistent opioid use among ICU survivors after discharge: incidence, predictors, and nationwide cohort analysis.Critical care (London, England) · 2025Article
- Pain and psychopathology after intensive care unit admission.Anaesthesia and intensive care · 2024Article
- Long term opioid use after burn injury: a retrospective cohort study.British journal of anaesthesia · 2024Article
- Pain Management Strategies in Intensive Care Unit: Challenges and Best Practice.Galen medical journal · 2024Article
- Clinical and Demographic Factors Associated with Receiving an Opioid Prescription following Admission to the Pediatric Intensive Care Unit.Children (Basel, Switzerland) · 2022Article
- Neurological toll of COVID-19.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Determinants of pain assessment documentation in intensive care units.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2021Article
- Reducing Opioid Use in Patients Undergoing Cardiac Surgery - Preoperative, Intraoperative, and Critical Care Strategies.Journal of cardiothoracic and vascular anesthesia · 2021Review
- Long-term outcomes after critical illness: recent insights.Critical care (London, England) · 2021Article
- Adjuvant Analgesic Use in the Critically Ill: A Systematic Review and Meta-Analysis.Critical care explorations · 2020Article
- COVID-19 Pandemic Acute Respiratory Distress Syndrome Survivors: Pain After the Storm?Anesthesia and analgesia · 2020Article
- The Effect of the Open and Closed System Suctions on Pain Severity and Physiological Indicators in Mechanically Ventilated Patients with Traumatic Brain Injury: A Randomised Controlled Trial.Turkish journal of anaesthesiology and reanimation · 2020Article
- Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Almost half of patients treated on intensive care unit (ICU) experience moderate to severe pain. Managing pain in the critically ill patient is challenging, as their pain is complex with multiple causes. Pharmacological treatment often focuses on opioids, and over a prolonged admission this can represent high cumulative doses which risk opioid dependence at discharge. Despite analgesia the incidence of chronic pain after treatment on ICU is high ranging from 33-73%. Measures need to be taken to prevent the transition from acute to chronic pain, whilst avoiding opioid overuse. This narrative review discusses preventive measures for the development of chronic pain in ICU patients. It considers a number of strategies that can be employed including non-opioid analgesics, regional analgesia, and non-pharmacological methods. We reason that individualized pain management plans should become the cornerstone for critically ill patients to facilitate physical and psychological well being after discharge from critical care and hospital.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.