Evidence map›Paper›PMID 30853902›Full record

ArticleFrontiers in neuroanatomy2019

Resting State Functional Connectivity of the Rat Claustrum.

Samuel R Krimmel, Houman Qadir, Natalie Hesselgrave, Michael G White, David H Reser, Brian N Mathur, David A Seminowicz

Erratum issuedAbstract read
In one paragraph

Article in Frontiers in neuroanatomy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. The Role of Claustrum in Incubation of Opioid Seeking after Electric Barrier-Induced Voluntary Abstinence in Male and Female Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Resting-state functional connectivity of the marmoset claustrum.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A Role for the Claustrum in Salience Processing?Frontiers in neuroanatomy · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Samuel R KrimmelCenter to Advance Chronic Pain Research, Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD, United States.
Houman QadirDepartment of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD, United States.
Natalie HesselgraveDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, MD, United States.
Michael G WhiteDepartment of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD, United States.
David H ReserGraduate Entry Medicine Program, Monash Rural Health-Churchill, Churchill, VIC, Australia.
Brian N MathurDepartment of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD, United States.
David A SeminowiczCenter to Advance Chronic Pain Research, Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD, United States.

Funding

TRAINING PROGRAM IN INTEGRATIVE MEMBRANE BIOLOGYT32GM008181 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE · PI RIZZO, MEGAN A, TRUDEAU, MATTHEW C · 1987 to 2022
$4.9M
Training Program in NeuroscienceT32NS063391 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI Jessica Aurora Mong · 2008 to 2026
$4.0M
Striatal Microcircuit Dynamics of Ethanol HabitsR01AA024845 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI BRIAN NEIL MATHUR · 2016 to 2026
$3.9M
MRI outcomes of mindfulness meditation for migraineR01AT007176 · NCCIH · UNIVERSITY OF MARYLAND BALTIMORE · PI SEMINOWICZ, DAVID · 2013 to 2017
$3.5M
Ethanol Remodeling of Striatal MicrocircuitsK22AA021414 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI MATHUR, BRIAN NEIL · 2013 to 2015
$658k
NCCIH NIH HHS R01 AT007176NIAAA NIH HHS K22 AA021414NIAAA NIH HHS R01 AA024845NIGMS NIH HHS T32 GM008181NINDS NIH HHS T32 NS063391
6 · The paper itself

Abstract

The claustrum is structurally connected with many cortical areas.A major hurdle standing in the way of understanding claustrum function is the difficulty in assessing the global functional connectivity (FC) of this structure. The primary issues lie in the inability to isolate claustrum signal from the adjacent insular cortex (Ins), caudate/putamen (CPu), and endopiriform nucleus (Endo). To address this issue, we used (7T) fMRI in the rat and describe a novel analytic method to study claustrum without signal contamination from the surrounding structures. Using this approach, we acquired claustrum signal distinct from Ins, CPu, and Endo, and used this claustrum signal to determine whole brain resting state functional connectivity (RSFC). Claustrum RSFC was distinct from the adjacent structures and displayed extensive connections with sensory cortices and the cingulate cortex, consistent with known structural connectivity of the claustrum. These results suggest fMRI and improved analysis can be combined to accurately assay claustrum function.

Indexed as

anterior cingulate cortexcaudatecortexforebraininsulaputamenstriatumtop-down

Identifiers

PMID30853902
PMCPMC6395398

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.