Evidence map›Paper›PMID 30853885›Full record

ArticleFrontiers in molecular neuroscience2019

Neurocalcin Delta Knockout Impairs Adult Neurogenesis Whereas Half Reduction Is Not Pathological.

Aaradhita Upadhyay, Seyyedmohsen Hosseinibarkooie, Svenja Schneider, Anna Kaczmarek, Laura Torres-Benito, Natalia Mendoza-Ferreira, Melina Overhoff, Roman Rombo, Vanessa Grysko, Min Jeong Kye and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  6. [Research progress on phenotypic modifier genes in spinal muscular atrophy].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Review
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  14. Spinal muscular atrophy.Nature reviews. Disease primers · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Aaradhita UpadhyayInstitute of Human Genetics, University of Cologne, Cologne, Germany.
Seyyedmohsen HosseinibarkooieInstitute of Human Genetics, University of Cologne, Cologne, Germany.
Svenja SchneiderInstitute of Human Genetics, University of Cologne, Cologne, Germany.
Anna KaczmarekInstitute of Human Genetics, University of Cologne, Cologne, Germany.
Laura Torres-BenitoInstitute of Human Genetics, University of Cologne, Cologne, Germany.
Natalia Mendoza-FerreiraInstitute of Human Genetics, University of Cologne, Cologne, Germany.
Melina OverhoffInstitute for Genetics, University of Cologne, Cologne, Germany.
Roman RomboInstitute of Human Genetics, University of Cologne, Cologne, Germany.
Vanessa GryskoInstitute of Human Genetics, University of Cologne, Cologne, Germany.
Min Jeong KyeInstitute of Human Genetics, University of Cologne, Cologne, Germany.
Natalia L KononenkoInstitute for Genetics, University of Cologne, Cologne, Germany.
Brunhilde WirthInstitute of Human Genetics, University of Cologne, Cologne, Germany.
University of Cologne · DECologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DEUniversity Hospital Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurocalcin delta (NCALD) is a brain-enriched neuronal calcium sensor and its reduction acts protective against spinal muscular atrophy (SMA). However, the physiological function of NCALD and implications of NCALD reduction are still elusive. Here, we analyzed the ubiquitous

Indexed as

adult neurogenesisMAP3K10neurocalcin deltaneuronal calcium sensorpJNK activationspinal muscular atrophysurvival motor neuron

Identifiers

PMID30853885
PMCPMC6396726
OpenAlexW2913432075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.