Evidence map›Paper›PMID 30853849›Full record

ArticleJournal of thermal analysis and calorimetry2019

Binding thermodynamics of metal ions to HIV-1 ribonuclease H domain.

Masayuki Oda, Zhaoyong Xi, Satomi Inaba, Ryan L Slack, Rieko Ishima

Abstract read
In one paragraph

Article in Journal of thermal analysis and calorimetry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Pharmacophores of Influenza Virus PA Endonuclease Inhibitors.Advances in experimental medicine and biology · 2026
    Review
  2. Structural basis for CaBiophysics and physicobiology · 2021
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Masayuki OdaGraduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Hangi-cho, Shimogamo, Sakyo-ku, Kyoto, Kyoto 606-8522, Japan.
Zhaoyong XiDepartment of Structural Biology, University of Pittsburgh School of, Medicine, Pittsburgh, Pennsylvania 15260, United States.
Satomi InabaGraduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Hangi-cho, Shimogamo, Sakyo-ku, Kyoto, Kyoto 606-8522, Japan.
Ryan L SlackDepartment of Structural Biology, University of Pittsburgh School of, Medicine, Pittsburgh, Pennsylvania 15260, United States.
Rieko IshimaDepartment of Structural Biology, University of Pittsburgh School of, Medicine, Pittsburgh, Pennsylvania 15260, United States.
University of Pittsburgh · USKyoto Prefectural University · JP

Funding

X-Ray Core P50GM082251 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALERO, GUILLERMO ALBERTO · 2007 to 2018
$48.1M
Technology Development 2: MAS NMR and dynamic nuclear polarization for HIV-1 structural biologyP50AI150481 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRONENBORN, ANGELA M. · 2019 to 2021
$14.1M
Conformational Dynamics and inhibitor responses of HIV-1 RT RNase H in solutionR01GM105401 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ISHIMA, RIEKO · 2013 to 2016
$1.4M
NIAID NIH HHS P50 AI150481NIGMS NIH HHS P50 GM082251NIGMS NIH HHS R01 GM105401
6 · The paper itself

Abstract

Metal-protein interactions are not necessarily tight in many transient biological processes, such as cellular signaling, enzyme regulation, and molecular recognition. Here, we analyzed the binding thermodynamics and characterized the structural effect of divalent metal ions, i.e. Mn

Indexed as

circular dichroismco-factorisothermal titration calorimetrymetal-protein interactionRNase H

Identifiers

PMID30853849
PMCPMC6402781
OpenAlexW2806842034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.