Evidence map›Paper›PMID 30853756›Full record

ArticleStatistica Sinica2018

SENSITIVITY ANALYSIS FOR UNMEASURED CONFOUNDING IN COARSE STRUCTURAL NESTED MEAN MODELS.

Shu Yang, Judith J Lok

Abstract read
In one paragraph

Article in Statistica Sinica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Data fusion methods for the heterogeneity of treatment effect and confounding function.Bernoulli : official journal of the Bernoulli Society for Mathematical Statistics and Probability · 2025
    Article
  3. Article
  4. Estimating spatially varying health effects of wildland fire smoke using mobile health data.Journal of the Royal Statistical Society. Series C, Applied statistics · 2024
    Article
  5. Article
  6. Article
  7. Multiply robust matching estimators of average and quantile treatment effects.Scandinavian journal of statistics, theory and applications · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shu YangDepartment of Statistics, North Carolina State University, Raleigh, NC 27695, USA. syang24@ncsu.edu.
Judith J LokDepartment of Biostatistics, Harvard University, Massachusetts, MA 02115, USA. jlok@hsph.harvard.edu.

Funding

VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sara Gianella Weibel · 1994 to 2026
$78.4M
Transmission ProbabilityP01AI074621 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RICHMAN, DOUGLAS D · 2008 to 2012
$23.1M
Primary Infection Resource Consortium (PIRC)R24AI106039 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LITTLE, SUSAN JANET · 2013 to 2021
$23.1M
Southern California Primary Infection ProgramU01AI043638 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RICHMAN, DOUGLAS D · 1998 to 2010
$21.3M
Analytic Methods for HIV Treatment and Co-Factor EffectsR37AI032475 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ROBINS, JAMES M · 2005 to 2014
$6.0M
Methods to Advance the HIV Prevention Research AgendaR37AI051164 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEGRUTTOLA, VICTOR GERARD · 2012 to 2019
$3.3M
Methods to find and model predictors of the causal effect of HAARTR01AI100762 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI LOK, JUDITH JACQUELINE · 2012 to 2015
$1.3M
NIAID NIH HHS P01 AI074621NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI100762NIAID NIH HHS R24 AI106039NIAID NIH HHS R37 AI032475NIAID NIH HHS R37 AI051164NIAID NIH HHS U01 AI043638
6 · The paper itself

Abstract

Coarse Structural Nested Mean Models (SNMMs, Robins (2000)) and G-estimation can be used to estimate the causal effect of a time-varying treatment from longitudinal observational studies. However, they rely on an untestable assumption of no unmeasured confounding. In the presence of unmeasured confounders, the unobserved potential outcomes are not missing at random, and standard G-estimation leads to biased effect estimates. To remedy this, we investigate the sensitivity of G-estimators of coarse SNMMs to unmeasured confounding, assuming a nonidentifiable bias function which quantifies the impact of unmeasured confounding on the average potential outcome. We present adjusted G-estimators of coarse SNMM parameters and prove their consistency, under the bias modeling for unmeasured confounding. We apply this to a sensitivity analysis for the effect of the ART initiation time on the mean CD4 count at year 2 after infection in HIV-positive patients, based on the prospective Acute and Early Disease Research Program.

Indexed as

Censoringconfounding by indicationestimating equationsHIV/AIDS researchnon-ignorablesequential randomization

Identifiers

PMID30853756
PMCPMC6407869

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.