Evidence map›Paper›PMID 30853741›Full record

ArticleJournal of food engineering2017

Purification of caprine oligosaccharides at pilot-scale.

Leticia F M C Aquino, Juliana M L N de Moura Bell, Joshua L Cohen, Yan Liu, Hyeyoung Lee, Vitor L de Melo Silva, Paola Domizio, Carlos Adam Conte, Daniela Barile

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Foods (Basel, Switzerland) · 2020
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Leticia F M C AquinoDepartment of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Juliana M L N de Moura BellDepartment of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Joshua L CohenDepartment of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Yan LiuDepartment of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Hyeyoung LeeDepartment of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Vitor L de Melo SilvaDepartment of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Paola DomizioDepartment of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
Carlos Adam ConteDepartment of Food Science and Technology, University Federal Fluminense, Niteroi, Rio de Janeiro, 24230340, Brazil.
Daniela BarileDepartment of Food Science and Technology, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States.
University of California, Davis · USUniversidade Federal Fluminense · BR

Funding

Activation of probiotic bifidobacteria by milk glyansR01AT008759 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2014 to 2018
$4.2M
Training Program in Biomolecular TechnologyT32GM008799 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEACH, J. KENT · 2002 to 2016
$2.4M
Mechanism of Activation of Probiotic Bifidobacteria by Prebiotic Milk GlycansR01AT007079 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GERMAN, BRUCE, LEBRILLA, CARLITO B · 2012 to 2016
$2.2M
NCCIH NIH HHS R01 AT007079NCCIH NIH HHS R01 AT008759NIGMS NIH HHS T32 GM008799
6 · The paper itself

Abstract

The purification of caprine milk oligosaccharides (COS) by membrane filtration has been hampered by the low concentration of target COS and high concentration of lactose. In addition, their molecular weight proximity hinders the recovery of a COS fraction with high degree of purity and recovery yield. In this work, the recovery of a high purity COS concentrate was obtained by the optimization of an integrated approach including complete lactose hydrolysis, fermentation of the resulting monosaccharides and nanofiltration. All carbohydrates were quantified using High Performance Anion Exchange Chromatography with Pulsed Amperometric Detection (HPAEC PAD). Defatted goat whey was ultrafiltered with discontinuous diafiltrations to increase the recovery of COS in the whey permeate which was then subsequently concentrated by nanofiltration. COS recovery yields of 75% with negligible amounts of monosaccharides (0.3% of the initial amount of lactose in the whey permeate) were achieved. A final retentate containing 67.6 and 34.4% of acidic and neutral oligosaccharides respectively was obtained from caprine milk.

Indexed as

Bioactive oligosaccharidesFermentationlactose hydrolysisMicrofiltrationNanofiltrationUltrafiltration

Identifiers

PMID30853741
PMCPMC6402817
OpenAlexW2621421489

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.