Evidence map›Paper›PMID 30853713›Full record

ArticleScientific reports2019

A blood-based signature of cerebrospinal fluid Aβ

Benjamin Goudey, Bowen J Fung, Christine Schieber, Noel G Faux, Alzheimer’s Disease Metabolomics Consortium, Alzheimer’s Disease Neuroimaging Initiative

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Association of Plasma AβNeurology · 2023
    Article
  3. Article
  4. Review
  5. 1Molecules (Basel, Switzerland) · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Diverse Applications of Artificial Intelligence in Neuroradiology.Neuroimaging clinics of North America · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 20 institutions in 6 countries.

Benjamin GoudeyIBM Research Australia, Carlton, Victoria, Australia.ORCID 0000-0002-2318-985X
Bowen J FungIBM Research Australia, Carlton, Victoria, Australia.ORCID 0000-0001-9177-6725
Christine SchieberIBM Research Australia, Carlton, Victoria, Australia.
Noel G FauxIBM Research Australia, Carlton, Victoria, Australia. noel.faux@au1.ibm.com.ORCID 0000-0003-4594-8818
Alzheimer’s Disease Metabolomics Consortium
Alzheimer’s Disease Neuroimaging Initiative
Duke Medical Center · USColumbia University Irving Medical Center · USNew York University · USIndiana University · USNorthwestern University · USUniversity of Alabama at Birmingham · USUniversity of California San Diego · USBoston University · USCalifornia University of Pennsylvania · USOregon Health & Science University · USUniversity of California, Davis · USUniversity of California, Irvine · USUniversity of California, Los Angeles · USUniversity of Kentucky · USUniversity of Rochester Medical Center · USUniversity of Wisconsin–Madison · USBaylor College of Medicine · USMayo Clinic in Florida · USStanford University · USWake Forest University · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
NCATS NIH HHS UL1 TR002369NIA NIH HHS P30 AG010129NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

It is increasingly recognized that Alzheimer's disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect for the success of interventions aimed at slowing down rates of cognitive decline. Recent evidence indicates that of the two established methods for measuring amyloid, a decrease in cerebrospinal fluid (CSF) amyloid β

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesApolipoproteins EBiomarkersChemokine CCL26Chromogranin AFemaleHumansMalePeptide FragmentsPredictive Value of TestsAmyloid beta-Peptidesamyloid beta-protein (1-42)Apolipoproteins EBiomarkersChemokine CCL26Chromogranin APeptide Fragments

Identifiers

PMID30853713
PMCPMC6409361
OpenAlexW2952623113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.