Evidence map›Paper›PMID 30853467›Full record

SynthesisBrazilian journal of otorhinolaryngology

Polymorphism in GRHL2 gene may contribute to noise-induced hearing loss susceptibility: a meta-analysis.

Xin Li, Zhengping Zhu, Wei Li, Li Wei, Baocheng Zhao, Zheng Hao

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brazilian journal of otorhinolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Polymorphisms and NIHL: a systematic review and meta-analyses.Frontiers in cellular neuroscience · 2023
    Pooled it
  2. Review
  3. Grainyhead-like 2 as a double-edged sword in development and cancer.American journal of translational research · 2020
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xin LiNanjing Municipal Center for Disease Control and Prevention, Department of HIV/AIDS/STI Prevention and Control, Jiangsu, China.
Zhengping ZhuNanjing Municipal Center for Disease Control and Prevention, Department of HIV/AIDS/STI Prevention and Control, Jiangsu, China.
Wei LiSoutheast University, School of Public Health, Department of Epidemiology and Health Statistics, Key Laboratory of Environmental Medicine Engineering, Jiangsu, China.
Li WeiNanjing Municipal Center for Disease Control and Prevention, Environmental Health Division, Jiangsu, China.
Baocheng ZhaoNanjing Zhongyangmen Community Health Service Center, Kang'ai Hospital, Center of Diagnosis and Treatment for Developmental Dysplasia of the Hip, Jiangsu, China.
Zheng HaoNanjing Zhongyangmen Community Health Service Center, Kang'ai Hospital, Center of Diagnosis and Treatment for Developmental Dysplasia of the Hip, Jiangsu, China. Electronic address: charliehao@msn.com.
Nanjing Municipal Center for Disease Control And Prevention · CNCommunity Health Center · USSoutheast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

instructionNoise-induced hearing loss is a leading occupational disease caused by gene-environment interaction. The Grainy Like 2, GRHL2, is a candidate gene. In this regard, many studies have evaluated the association between GRHL2 and noise-induced hearing loss, although the results are ambiguous and conflicting.

objectiveThe purpose of this study was to identify a precise estimation of the association between rs3735715 polymorphism in GRHL2 gene and susceptibility of noise-induced hearing loss.

methodsA comprehensive search was performed to collect data up to July 8, 2018. Finally, 4 eligible articles were included in this meta-analysis comprising 2410 subjects. The pooled odds ratios with 95% confidence intervals were used to evaluate the strength of the association.

resultsSignificant association was found in the overall population in the dominant model (GA/AA vs. GG, odds ratio=0.707, 95% confidence interval=0.594-0.841) and allele model (G allele vs. A allele, odds ratio=1.189, 95% confidence interval=1.062-1.333). When stratified by source of the subjects, we also found association between rs3735715 and noise-induced hearing loss risk in the dominant model (GA/AA vs. GG, odds ratio=0.634, 95% confidence interval=0.514-0.783) and allele model (G allele vs. A allele, odds ratio=1.206, 95% confidence interval=1.054-1.379).

conclusionRs3735715 polymorphism in GRHL2 gene may influence the susceptibility of noise-induced hearing loss. Additional large, well-designed and functional studies are needed to confirm this association in different populations.

Indexed as

DNA-Binding ProteinsGenetic Predisposition to DiseaseGenotypeHearing Loss, Noise-InducedHumansNoise, OccupationalOccupational DiseasesPolymorphism, Single NucleotideTranscription FactorsDNA-Binding ProteinsGRHL2 protein, humanTranscription FactorsEpidemiologia molecularGrainyhead like 2Meta-analysisMetanáliseMolecular epidemiologyNoise-induced hearing lossPerda auditiva induzida por ruídoPolimorfismoPolymorphism

Identifiers

PMID30853467
PMCPMC9422585
OpenAlexW2916963656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.