ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2019
The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Plasma eMTBR-tau243 as a disease biomarker across Alzheimer's disease clinical phenotypes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Diagnostic utility of tectal plate measures in clinical variants of progressive supranuclear palsy.Journal of neurology · 2025Article
- AβJournal of Alzheimer's disease : JAD · 2025Article
- White matter hyperintensities in dementia with lewy bodies and posterior cortical atrophy.Neurobiology of aging · 2025Article
- Relationship between tau-PET and quantitative susceptibility mapping in atypical Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Investigating the feasibility ofAlzheimer's & dementia : the journal of the Alzheimer's Association · 2024Observational
- Relationships between PET and blood plasma biomarkers in corticobasal syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Atypical Alzheimer's disease: new insights into an overlapping spectrum between the language and visual variants.Journal of neurology · 2024Article
- Altered structural and functional connectivity in Posterior Cortical Atrophy and Dementia with Lewy bodies.NeuroImage · 2024Article
- Longitudinal default mode sub-networks in the language and visual variants of Alzheimer's disease.Brain communications · 2024Article
- Atypical clinical variants of Alzheimer's disease: are they really atypical?Frontiers in neuroscience · 2024Article
- Molecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.Brain communications · 2024Article
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment.Alzheimer's research & therapy · 2023Article
- Network anatomy in logopenic variant of primary progressive aphasia.Human brain mapping · 2023Article
- Based on Tau PET Radiomics Analysis for the Classification of Alzheimer's Disease and Mild Cognitive Impairment.Brain sciences · 2023Article
- Article
- Altered within- and between-network functional connectivity in atypical Alzheimer's disease.Brain communications · 2023Article
- Atypical Alzheimer's disease phenotypes with normal or borderline PET biomarker profiles.Journal of neurology · 2022Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
introductionLittle is known about the role of age on neurodegeneration and protein deposition in atypical variants of Alzheimer's disease (AD).
methodsRegional tau and β-amyloid positron emission tomography standard uptake value ratios and gray matter volumes were calculated in a cohort of 42 participants with atypical AD. The relationship between regional metrics and age was modeled using a Bayesian hierarchical linear model.
resultsAge was strongly associated with tau uptake across all cortical regions, particularly parietal, with greater uptake in younger participants. Younger age was associated with smaller parietal and lateral temporal volumes. Regional β-amyloid differed little by age. Age showed a stronger association with tau than volume and β-amyloid in all cortical regions. Age was not associated with cognitive performance. DISCUSSION: Age is an important determinant of severity of cortical tau uptake in atypical AD, with young participants more likely to show widespread and severe cortical tau uptake.
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