Evidence map›Paper›PMID 30853441›Full record

ArticleDevelopmental cell2019

FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.

Hongtao Zhang, Mazdak Bagherie-Lachidan, Caroline Badouel, Leonie Enderle, Philippos Peidis, Rod Bremner, Satu Kuure, Sanjay Jain, Helen McNeill

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

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  15. Metabolic programming of nephron progenitor cell fate.Pediatric nephrology (Berlin, Germany) · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Hongtao ZhangLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Mazdak Bagherie-LachidanLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Caroline BadouelLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Centre de Biologie du Développement (CBD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 Route de Narbonne, Toulouse 31062, France.
Leonie EnderleLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Philippos PeidisLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Rod BremnerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Departments of Ophthalmology and Visual Science, and Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Satu KuureGM-unit at Laboratory Animal Centre, HiLIFE and Medicum, University of Helsinki, Helsinki 00014, Finland.
Sanjay JainDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Helen McNeillLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: mcneillh@wustl.edu.
Mount Sinai Hospital · CAUniversity of Helsinki · FIWashington University in St. Louis · US

Funding

NOVEL MECHANISMS REGULATING LOWER URINARY TRACT DEVELOPMENT AND INNERVATIONR01DK082531 · NIDDK · WASHINGTON UNIVERSITY · PI JAIN, SANJAY · 2009 to 2018
$3.3M
NIDDK NIH HHS R01 DK082531
6 · The paper itself

Abstract

FAT4 mutations lead to several human diseases that disrupt the normal development of the kidney. However, the underlying mechanism remains elusive. In studying the duplex kidney phenotypes observed upon deletion of Fat4 in mice, we have uncovered an interaction between the atypical cadherin FAT4 and RET, a tyrosine kinase receptor essential for kidney development. Analysis of kidney development in Fat4

Indexed as

Signal TransductionAnimalsCadherinsGene DeletionGlial Cell Line-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic Factor ReceptorsHumansIntercellular Signaling Peptides and ProteinsKidneyMiceNerve Tissue ProteinsProtein BindingProto-Oncogene Proteins c-retUp-RegulationCadherinsDchs1 protein, mouseFat4 protein, mouseFjx1 protein, mouseGfra1 protein, mouseGlial Cell Line-Derived Neurotrophic FactorGlial Cell Line-Derived Neurotrophic Factor ReceptorsIntercellular Signaling Peptides and ProteinsNerve Tissue ProteinsProto-Oncogene Proteins c-retcadherinCAKUTFAT4kidney developmentnon-autonomousRETVan Maldergem syndrome

Identifiers

PMID30853441
PMCPMC6766079
OpenAlexW2920926194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.