ArticleVirchows Archiv. A, Pathological anatomy and histopathology1986
Primary mediastinal clear cell lymphoma of B-cell type.
Article in Virchows Archiv. A, Pathological anatomy and histopathology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 122 citations in OpenAlex.
- Mediastinal large B cell lymphoma and surrounding gray areas: a report of the lymphoma workshop of the 20th meeting of the European Association for Haematopathology.Virchows Archiv : an international journal of pathology · 2023Review
- Role of Specific B-Cell Receptor Antigens in Lymphomagenesis.Frontiers in oncology · 2020Review
- Genomic analyses of PMBL reveal new drivers and mechanisms of sensitivity to PD-1 blockade.Blood · 2019Article
- Article
- Primary mediastinal DLBCL: evolving biologic understanding and therapeutic strategies.Current oncology reports · 2011Review
- Primary mediastinal large B-cell lymphoma, classic Hodgkin lymphoma presenting in the mediastinum, and mediastinal gray zone lymphoma: what is the oncologist to do?Current hematologic malignancy reports · 2011Review
- Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France.Journal of hematopathology · 2009Article
- Article
- [Mediastinal large B-cell lymphoma].Der Pathologe · 2007Article
- Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomas.The American journal of pathology · 1995Article
- PMA-activation of peripheral blood and tonsillar B lymphocytes induces large adhesive cells reminiscent of large extrafollicular (monocytoid) B cells.Virchows Archiv : an international journal of pathology · 1994Article
- Childhood B cell lymphomas arising in the mediastinum.Journal of clinical pathology · 1993Article
- Adhesion receptor profile of thymic B-cell lymphoma.The American journal of pathology · 1992Article
- Venular endothelium binding molecules CD44 and LECAM-1 in normal and malignant B-cell populations. A comparative study.Virchows Archiv. A, Pathological anatomy and histopathology · 1992Article
- Tumours of the thymus and their nomenclature.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Review
- Intra- and extrathymic B cells in physiologic and pathologic conditions. Immunohistochemical study on normal thymus and lymphofollicular hyperplasia of the thymus.Virchows Archiv. A, Pathological anatomy and histopathology · 1988Article
- Mediastinal large-cell lymphoma with sclerosis. Genotypic analysis establishes its B nature.Virchows Archiv. A, Pathological anatomy and histopathology · 1987Article
- Molecular Classification and Treatment of Diffuse Large B-Cell Lymphoma and Primary Mediastinal B-Cell Lymphoma.Cancer journal (Sudbury, Mass.)Review
- Primary mediastinal lymphomas, their morphological features and comparative evaluation.Lung India : official organ of Indian Chest SocietyArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This is a report on 8 mediastinal tumours that occurred in young adults (19-43 years, mean: 29.4); predominantly in females (6/8). Initial symptoms consisted of thoracic pain and venectasia and in only one case in B symptoms. After surgical tumour reduction, radiation and/or chemotherapy, local recurrence was observed in each case under clinical care; abdominal spread is presently suspected in 3 patients; 3 died 11, 13 and 22 months after diagnosis. None developed leukaemia. The tumours are B-cell neoplasms with a characteristic immunophenotype: leucocyte common antigen+, common acute lymphoblastic leukaemia antigen-, B 1-antigen+, surface and cytoplasmic immunoglobulin-. Flow cytometry revealed DNA-diploidy in 7 cases and a moderately (3.2-3.8%) to extremely high (8.0-20.6%) S-phase component. The proliferation associated antigen Ki67 was detectable in 10-60% of the tumour cell nuclei, thus stressing the considerable or rapid growth. Histopathology is characterized by a diffuse growth pattern and a clearness and abundance of cytoplasm of the pleomorphic tumour cells, which vary in size and nuclear morphology from patient to patient. Apoptoses are more numerous than mitoses. Fibrosis and focal necrosis are common, sclerosis is present in 3 cases. We suggest that primary mediastinal lymphoma of B cell type is a novel B-lymphoma variant.
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