ArticlePediatric neurology2019
Physical and Family History Variables Associated With Neurological and Cognitive Development in Sturge-Weber Syndrome.
Article in Pediatric neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
- Epilepsy, Cognitive, and Behavioral Outcomes in Neurocutaneous Syndromes: A Comparative Review of NF1, TSC, and Sturge-Weber Syndrome.Children (Basel, Switzerland) · 2026Review
- Development and Retrospective Application of Novel Outcome Measure: Sturge-Weber Syndrome Acute Crisis (SWAC) Index.Annals of the Child Neurology Society · 2026Article
- Steroids for Drug-Resistant Seizures and Prolonged Stroke-Like Episode in a Patient With Sturge-Weber Syndrome: A Case Report.Annals of the Child Neurology Society · 2026Article
- Acute Seizure Susceptibility and Chronic Vascular Malformation in a Developmental Mouse Model of Sturge-Weber Syndrome.International journal of molecular sciences · 2026Article
- Coping Strategies and Sense of Care Among Parents of Children Affected by Sturge-Weber Syndrome: A Cross-Sectional Study.Nursing reports (Pavia, Italy) · 2026Article
- Biomarker development in Sturge-Weber syndrome.Journal of neurodevelopmental disorders · 2025Review
- Sturge Weber syndrome in a multinational pediatric cohort: a systematic analysis of different types.Orphanet journal of rare diseases · 2025Observational
- Transcriptomic Profiling Unveils EDN3Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- New Trigger for Stroke-like Episode in Sturge-Weber Syndrome: A Case Report.Children (Basel, Switzerland) · 2025Article
- Feasibility and Potential Diagnostic Value of Noncontrast Brain MRI in Nonsedated Children With Sturge-Weber Syndrome and Healthy Siblings.Journal of child neurology · 2024Article
- Longitudinal prospective study of Sturge-Weber syndrome urine angiogenic factors and neurological outcome.Annals of the Child Neurology Society · 2024Article
- Capillary malformations.The Journal of clinical investigation · 2024Review
- Neurological function and drug-refractory epilepsy in Sturge-Weber syndrome children: a retrospective analysis.European journal of pediatrics · 2024Article
- Neurocutaneous Diseases: Diagnosis, Management, and Treatment.Journal of clinical medicine · 2024Review
- Retrospective Analysis of Presymptomatic Treatment In Sturge-Weber Syndrome.Annals of the Child Neurology Society · 2024Article
- Sturge-Weber syndrome: Updates in pathogenesis, diagnosis, and treatment.Annals of the Child Neurology Society · 2023Review
- Deep Venous Remodeling in Unilateral Sturge-Weber Syndrome: Robust Hemispheric Differences and Clinical Correlates.Pediatric neurology · 2023Article
- Sturge-Weber Syndrome: A Review of Pathophysiology, Genetics, Clinical Features, and Current Management Approache.The application of clinical genetics · 2023Review
- Updates on Sturge-Weber Syndrome.Stroke · 2022Review
- Atlas of Nervous System Vascular Malformations: A Systematic Review.Life (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
20 authors at 13 institutions in 1 country.
Funding
Abstract
backgroundSturge-Weber syndrome (SWS) is caused by a somatic mutation in GNAQ leading to capillary venous malformations in the brain presenting with various neurological, ophthalmic, and cognitive symptoms of variable severity. This clinical variability makes accurate prognosis difficult. We hypothesized that the greater extent of physical factors (extent of skin, eye, and brain involvement), presence of possible genetic factors (gender and family history), and age of seizure onset may be associated with greater symptom severity and need for surgery in patients with SWS.
methodsThe questionnaire was collected from 277 participants (age: two months to 66 years) with SWS brain involvement at seven US sites.
resultsBilateral brain involvement was associated with both learning disorder and intellectual disability, whereas port-wine birthmark extent was associated with epilepsy and an increased likelihood of glaucoma surgery. Subjects with family history of vascular birthmarks were also more likely to report symptomatic strokes, and family history of seizures was associated with earlier seizure onset. Learning disorder, intellectual disability, strokelike episodes, symptomatic stroke, hemiparesis, visual field deficit, and brain surgery were all significantly associated with earlier onset of seizures.
conclusionThe extent of brain and skin involvement in SWS, as well as the age of seizure onset, affect prognosis. Other genetic factors, particularly variants involved in vascular development and epilepsy, may also contribute to neurological prognosis, and further study is needed.
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