Evidence map›Paper›PMID 30852892›Full record

ArticleJournal of medicinal chemistry2019

Coagulation Factor XIIIa Inhibitor Tridegin: On the Role of Disulfide Bonds for Folding, Stability, and Function.

Charlotte A Bäuml, Thomas Schmitz, Ajay Abisheck Paul George, Monica Sudarsanam, Kornelia Hardes, Torsten Steinmetzer, Lori A Holle, Alisa S Wolberg, Bernd Pötzsch, Johannes Oldenburg and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Fibrinogen and Factor XIII in Venous Thrombosis and Thrombus Stability.Arteriosclerosis, thrombosis, and vascular biology · 2022
    Review
  4. Recombinant Destabilase fromCurrent issues in molecular biology · 2021
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Charlotte A BäumlPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute , University of Bonn , An der Immenburg 4 , 53121 Bonn , Germany.
Thomas SchmitzPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute , University of Bonn , An der Immenburg 4 , 53121 Bonn , Germany.
Ajay Abisheck Paul GeorgePharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute , University of Bonn , An der Immenburg 4 , 53121 Bonn , Germany.
Monica SudarsanamPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute , University of Bonn , An der Immenburg 4 , 53121 Bonn , Germany.
Kornelia HardesInstitute of Pharmaceutical Chemistry , Philipps University of Marburg , Marbacher Weg 6 , 35032 Marburg , Germany.
Torsten SteinmetzerInstitute of Pharmaceutical Chemistry , Philipps University of Marburg , Marbacher Weg 6 , 35032 Marburg , Germany.ORCID 0000-0001-6523-4754
Lori A HolleDepartment of Pathology and Laboratory Medicine , University of North Carolina at Chapel Hill , 819 Brinkhous-Bullitt Building , Chapel Hill , North Carolina 27599 , United States.
Alisa S WolbergDepartment of Pathology and Laboratory Medicine , University of North Carolina at Chapel Hill , 819 Brinkhous-Bullitt Building , Chapel Hill , North Carolina 27599 , United States.
Bernd PötzschInstitute of Experimental Hematology and Transfusion Medicine , University Hospital Bonn , Sigmund-Freud-Str. 25 , 53127 Bonn , Germany.
Johannes OldenburgInstitute of Experimental Hematology and Transfusion Medicine , University Hospital Bonn , Sigmund-Freud-Str. 25 , 53127 Bonn , Germany.
Arijit BiswasInstitute of Experimental Hematology and Transfusion Medicine , University Hospital Bonn , Sigmund-Freud-Str. 25 , 53127 Bonn , Germany.
Diana ImhofPharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute , University of Bonn , An der Immenburg 4 , 53121 Bonn , Germany.ORCID 0000-0003-4163-7334
University of Bonn · DEUniversity Hospital Bonn · DEPhilipps University of Marburg · DEUniversity of North Carolina at Chapel Hill · US

Funding

Fibrinogen and Factor XIII in Venous ThrombosisR01HL126974 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alisa S. Wolberg · 2016 to 2026
$4.4M
NHLBI NIH HHS R01 HL126974
6 · The paper itself

Abstract

Tridegin is a potent and specific 66mer peptide inhibitor of coagulation factor XIIIa with six cysteines involved in three disulfide bonds. Three of the 15 possible 3-disulfide-bonded isomers have been identified, which share a bridge between cysteines 19 and 25. We synthesized the three possible 2-disulfide-bonded analogues using a targeted protecting group strategy to investigate the impact of the C

Indexed as

AnimalsBlood CoagulationDisulfidesFactor XIIIaHumansIsomerismLeechesMolecular Dynamics SimulationProtein FoldingProtein StabilitySalivary Proteins and PeptidesDisulfidesFactor XIIIaSalivary Proteins and Peptidestridegin

Identifiers

PMID30852892
PMCPMC6650289
OpenAlexW2922103271

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.