ArticleUpdates in surgery2019
Dissecting the multinodular hepatocellular carcinoma subset: is there a survival benefit after hepatectomy?
Article in Updates in surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Outcome of hepatic resection for HCC in ideal and non-ideal candidates.Hepatology communications · 2025Article
- Case Report: Selective hepatic resection guided by indocyanine green short-wave infrared fluorescence imaging in a dog with multifocal liver lesions.Frontiers in veterinary science · 2025Article
- Value of magnetic resonance imaging for diagnosis of LR‑3 and LR-4 lesions coexisting with hepatocellular carcinoma.Abdominal radiology (New York) · 2024Article
- Development of prognostic models for advanced multiple hepatocellular carcinoma based on Cox regression, deep learning and machine learning algorithms.Frontiers in medicine · 2024Article
- Evaluating the best treatment for multifocal hepatocellular carcinoma: A propensity score-matched analysis.World journal of gastroenterology · 2022Article
- Rapid automated diagnosis of primary hepatic tumour by mass spectrometry and artificial intelligence.Liver international : official journal of the International Association for the Study of the Liver · 2020Article
- [Surgical treatment of hepatic tumors-liver resection and transplantation].Der Internist · 2020Review
- Article
- Liver resection for multifocal hepatocellular carcinoma: is it an option?Hepatobiliary surgery and nutrition · 2019Article
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8 authors.
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Abstract
Whether hepatic resection for multinodular hepatocellular carcinoma (HCC) is indicated remains to be demonstrated. We investigated the prognostic factors in a large series of patients treated with hepatic resection at a reference cancer center. All consecutive patients resected for multinodular HCC from January 2004 to April 2015 were reviewed. The study endpoints were the survival analysis and the definition of resection criteria. Among 380 patients resected for HCC, 116 (31%) were affected by multinodular HCC without macrovascular invasion. The median tumor number was 2 (range 2-30), while the median tumor size was 3.5 cm (range 1.1-28). The 90-day mortality was 2.6%. Morbidity was 31%. After a median follow-up of 31 months (range 3.1-149.7), the 1-, 3-, and 5-year overall survival rates were 85, 52, and 35%, respectively. At the multivariate analysis, tumor number more than 4 (HR = 2.15; 95% CI 1.8-4.18; P = 0.001), tumor size more than 6 cm (HR = 2.78; 95% CI 2.08-4.91; P = 0.001), esophageal varices (HR = 3.01; 95% CI 1.98-5.61; P = 0.002), and major hepatectomy (HR = 2.91; 95% CI 1.97-4.54; P = 0.001) were independently significant for survival. Median survival shifted from 20 to 52 months based on these factors. Hepatic resection for multinodular HCC may result in survival benefit for patients up to four tumors, none more than 6 cm, without varices, and eventually treated by conservative surgery.
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