Evidence map›Paper›PMID 30852803›Full record

ArticleNeuroscience bulletin2019

Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms.

Lingling Cui, Fei Wang, Miao Chang, Zhiyang Yin, Guoguang Fan, Yanzhuo Song, Yange Wei, Yixiao Xu, Yifan Zhang, Yanqing Tang and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Lingling CuiDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Fei WangDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Miao ChangDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Zhiyang YinDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Guoguang FanDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yanzhuo SongDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yange WeiDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yixiao XuDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yifan ZhangDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
Yanqing TangDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China. yanqingtang@163.com.
Xiaohong GongState Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, China. gongxh@fudan.edu.cn.
Ke XuDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China. kxu@cmu.edu.cn.
First Hospital of China Medical University · CNChina Medical University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia. However, the neural mechanisms underlying this association are unknown. Given that ZNF804A upregulates the expression of COMT, we hypothesized that ZNF804A may influence brain activity by interacting with COMT. Here, we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants. Amplitudes of low-frequency fluctuations (ALFFs) were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680. The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 × COMT rs4680 interaction, manifesting as a U-shaped modulation, presumably by dopamine signaling. Significant main effects were also found. These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT, and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia.

Indexed as

AdolescentAdultCatechol O-MethyltransferaseChinaDopamineFemaleGenetic Predisposition to DiseaseGenotypeHealthy VolunteersHumansKruppel-Like Transcription FactorsMagnetic Resonance ImagingMaleMiddle AgedPolymorphism, Single NucleotidePrefrontal CortexCatechol O-MethyltransferaseCOMT protein, humanDopamineKruppel-Like Transcription FactorsZNF804A protein, humanAmplitudes of low-frequency fluctuationsCatechol-O-methyltransferasefMRIZinc finger protein 804A

Identifiers

PMID30852803
PMCPMC6616604
OpenAlexW2922053886

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.