ArticleDigestive diseases and sciences2019
Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study.
Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The effect of Hp infection on dyslipidemia in Asia and out of Asia: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Association of Helicobacter pylori infection with elevated low-density lipoprotein cholesterol and fasting glucose: a large-scale analysis of 83,054 participants in central China.BMC infectious diseases · 2026Article
- Association of triglyceride-glucose index with Helicobacter pylori infection in the 1999-2000 NHANES cross-sectional study.Scientific reports · 2025Article
- Retrospective cohort study ofFrontiers in public health · 2025Article
- Relationship between Helicobacter Pylori infection and metabolic syndrome components in adults.Frontiers in endocrinology · 2025Article
- Causal associations of Helicobacter pylori infection and metabolic syndrome: insights from a two-sample Mendelian randomization study.Diabetology & metabolic syndrome · 2024Article
- Association between infection with Helicobacter pylori and metabolic syndrome among diabetic patients attending Jimma medical center in Jimma city, Ethiopia: a cross-sectional study.BMC infectious diseases · 2024Article
- Association of Helicobacter pylori infection with complications of diabetes: a single-center retrospective study.BMC endocrine disorders · 2024Article
- Metabolic syndrome and associated factors amongFrontiers in endocrinology · 2024Article
- The influence ofFrontiers in cellular and infection microbiology · 2024Article
- Effect ofJournal of neurogastroenterology and motility · 2023Article
- Long-term Effects of the Eradication ofGut and liver · 2023Article
- Changes in Metabolic Parameters byGut and liver · 2023Article
- Association betweenFrontiers in endocrinology · 2023Article
- Review
- Targeting metabolic pathways: a novel therapeutic direction for type 2 diabetes.Frontiers in cellular and infection microbiology · 2023Article
- Effect of Helicobacter pylori eradication on metabolic profile: an international, multicenter, case-control study.BMC gastroenterology · 2022Article
- Peptic Ulcer Disease Associated with Central Obesity.Journal of personalized medicine · 2022Article
- Long-term effect of the eradication of Helicobacter pylori on the hemoglobin A1c in type 2 diabetes or prediabetes patients.The Korean journal of internal medicine · 2022Article
- Eradication of Helicobacter pylori alleviates lipid metabolism deterioration: a large-cohort propensity score-matched analysis.Lipids in health and disease · 2022Article
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimHelicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population.
methodsAnthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria.
resultsAfter excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09-1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old.
conclusionsH. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.
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