ArticleEnvironmental science and pollution research international2019
The association between iron, calcium, and oxidative stress in seminal plasma and sperm quality.
Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05171504 (Detection of Lactoferrin and Iron in Seminal Plasma and Their Possible Relation to Fertility Status in Varicocele), which is not on this map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Detection of Lactoferrin and Iron in Seminal Plasma and Their Possible Relation to Fertility Status in Varicocele: A Case-control Study
Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- The Effect of Oral Vitamin E on Semen Parameters and IVF Outcome: A Double-Blinded Randomized Placebo-Controlled Clinical Trial.BioMed research international · 2021Trial
- Metals/Metalloids Profile in Seminal Plasma/Serum of Patients with Asthenozoospermia/Oligozoospermia: Correlation with Semen Quality.Biological trace element research · 2026Article
- The influence of environmental and chemical exposures on fertility in the Eastern Mediterranean region: A narrative review.International journal of reproductive biomedicine · 2025Review
- Multielemental Profile for Seminal Plasma Through Inductively Coupled Plasma-Tandem Mass Spectrometry and Its Relationship with Seminal Parameters, Spermatic Biomarkers, and Oxidative Stress.Antioxidants (Basel, Switzerland) · 2025Article
- Iron biomarkers in men with infertility are associated with sperm DNA hydroxymethylation and cumulative live birth rates: a prospective study.Journal of translational medicine · 2025Article
- Effects of PM2.5 Metal Components Derived From Porcine Farm Exposure on Sperm Function in Mice.Journal of biochemical and molecular toxicology · 2025Article
- Review
- Redox Homeostasis and Nrf2-Regulated Mechanisms Are Relevant to Male Infertility.Antioxidants (Basel, Switzerland) · 2024Review
- No evidence of genetic causation between iron and infertility: a Mendelian randomization study.Frontiers in nutrition · 2024Article
- Proteomic Analysis of Frozen-Thawed Spermatozoa with Different Levels of Freezability in Dairy Goats.International journal of molecular sciences · 2023Article
- Analytical Determination of Heavy Metals in Human Seminal Plasma-A Systematic Review.Life (Basel, Switzerland) · 2023Review
- Influence of Seminal Metals on Assisted Reproduction Outcome.Biological trace element research · 2023Article
- Bta-miR-6531 Regulates Calcium Influx in Bovine Leydig Cells and Is Associated with Sperm Motility.Genes · 2022Article
- The association between dietary fat and mineral intake with semen parameters: A cross-sectional study in infertile men.International journal of reproductive biomedicine · 2022Article
- Current markers for infertility in men.JBRA assisted reproduction · 2021Article
- Role of Antioxidants in Cooled Liquid Storage of Mammal Spermatozoa.Antioxidants (Basel, Switzerland) · 2021Review
- Trace element analysis of human seminal plasma: A cautionary tale of preanalytical variation and use of non-traditional matrices in human biomonitoring studies.International journal of hygiene and environmental health · 2021Article
- Nutrition, genetic variation and male fertility.Translational andrology and urology · 2021Review
- Association of Zinc deficiency, oxidative stress and increased double-stranded DNA breaks in globozoospermic infertile patients and its implication for the assisted reproductive technique.Translational andrology and urology · 2021Article
- Semen Biochemical Components in Varicocele, Leukocytospermia, and Idiopathic Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The present study aimed to determine the level of iron and calcium in the seminal plasma of men with different fertility potentials and to examine its relationship with oxidative stress. Seventy-nine sub-fertile patients with asthenoteratozoospermia (AT), n 27; teratoleucozoospermia (TL), n 20; teratozoospermia (Terato), n 32; and 29 healthy donors were included. The ability of spermatozoa to produce reactive oxygen species (ROS) was evaluated by using nitroblue tetrazolium (NBT) staining. The lipid peroxidation end product, malondialdehyde (MDA), and the trace element levels (iron and calcium) were measured spectrophotometrically. Iron and calcium concentrations in seminal plasma of the patient groups were significantly more elevated than the normal group. Nevertheless, both calcium and iron showed strong negative correlations with the total sperm motility and normal sperm morphology, but only iron was positively and significantly associated with multiple anomalies index and seminal leucocyte concentration. On the other hand, the rates of MDA and ROS production in semen were significantly higher in the three abnormal groups than in controls. These two oxidative stress biomarkers were significantly associated with the percentage of atypical forms in semen. However, only semen ROS level was significantly associated with the decreased sperm motility and the sperm leucocytes concentration. Meanwhile, there are positive correlations between seminal iron and calcium content and the studied oxidative stress biomarkers. Oxidative stress and trace element excess are implicated in low sperm quality. Iron and calcium might be the mediators of the effects of oxidative damage and induces lipid peroxidation.
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Registered trials
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