ArticleBrain imaging and behavior2020
Fitness, independent of physical activity is associated with cerebral blood flow in adults at risk for Alzheimer's disease.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Effects of 5 Years Aerobic Exercise on Cognition in Older Adults: The Generation 100 Study: A Randomized Controlled Trial.Sports medicine (Auckland, N.Z.) · 2022Trial
- Higher VOScientific reports · 2021Trial
- Brain Perfusion Change in Patients with Mild Cognitive Impairment After 12 Months of Aerobic Exercise Training.Journal of Alzheimer's disease : JAD · 2020Trial
- Rising energetic cost of walking predicts cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Physical Activity Patterns and Variability, Cognitive Performance, and Dementia in the National Health and Aging Trends Study.Medicine and science in sports and exercise · 2025Article
- Lifestyle interventions for dementia risk reduction: A review on the role of physical activity and diet in Western and Asian Countries.The journal of prevention of Alzheimer's disease · 2025Review
- Arterial spin labeling perfusion MRI in the Alzheimer's Disease Neuroimaging Initiative: Past, present, and future.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Article
- Independent and joint associations of cardiorespiratory fitness and BMI with dementia risk: the Cooper Center Longitudinal Study.BMJ open · 2023Article
- Associations between everyday activities and arterial spin labeling-derived cerebral blood flow: A longitudinal study in community-dwelling elderly volunteers.Human brain mapping · 2023Article
- Cognitive Function, and Its Relationships with Comorbidities, Physical Activity, and Muscular Strength in Korean Older Adults.Behavioral sciences (Basel, Switzerland) · 2023Article
- Getting Fit to Counteract Cognitive Aging: Evidence and Future Directions.Physiology (Bethesda, Md.) · 2022Review
- Healthy Food Pyramid as Well as Physical and Mental Activity in the Prevention of Alzheimer's Disease.Nutrients · 2022Review
- Five-year changes in objectively measured cardiorespiratory fitness, physical activity, and sedentary time in mid-to-late adulthood.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2022Article
- Mean arterial pressure, fitness, and executive function in middle age and older adults.Cerebral circulation - cognition and behavior · 2022Article
- A Randomized Controlled Trial on the Effects of a 12-Week High- vs. Low-Intensity Exercise Intervention on Hippocampal Structure and Function in Healthy, Young Adults.Frontiers in psychiatry · 2021Article
- Association of walking energetics with amyloid beta status: Findings from the Baltimore Longitudinal Study of Aging.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Cardiorespiratory fitness mitigates brain atrophy and cognitive decline in adults at risk for Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Beneficial Effects of Physical Activity on Subjects with Neurodegenerative Disease.Journal of functional morphology and kinesiology · 2020Article
- Potential Benefits of Physical Activity in MCI and Dementia.Behavioural neurology · 2020Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
Patterns of decreased resting cerebral blood flow (CBF) within the inferior temporal gyri, angular gyri, and posterior cingulate are a feature of aging and Alzheimer's disease (AD) and have shown to be predictive of cognitive decline among older adults. Fitness and physical activity are both associated with many indices of brain health and may positively influence CBF, however, the majority of research to date has examined these measures in isolation, leaving the potential independent associations unknown. The purpose of this study was to determine the unique contributions of fitness and physical activity when predicting CBF in cognitively healthy adults at risk for AD. One hundred participants (63% female) from the Wisconsin Registry for Alzheimer's Prevention underwent a maximal exercise test, physical activity monitoring, and a 3-D arterial spin labeling magnetic resonance imaging scan. For the entire sample, fitness was significantly associated with CBF while accounting for physical activity, age, gender, APOE ε4, family history of AD, education, and handedness (p = .026). Further, fitness explained significantly more variance than the combined effect of the covariates on CBF (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.