Evidence map›Paper›PMID 30852696›Full record

Trial reportNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Cortical and spinal excitability changes after repetitive transcranial magnetic stimulation combined to physiotherapy in stroke spastic patients.

Rebeka Borba Costa Dos Santos, Silvana Carla Barros Galvão, Labibe Mara Pinel Frederico, Nathália Serrano Lucena Amaral, Maíra Izzadora Souza Carneiro, Alberto Galvão de Moura Filho, Daniele Piscitelli, Kátia Monte-Silva

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 7 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 7 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Rebeka Borba Costa Dos SantosApplied Neuroscience Laboratory, Department of Physical Therapy, Avenida Jornalista Aníbal Fernandes s/n, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, 50740-560, Brazil.
Silvana Carla Barros GalvãoApplied Neuroscience Laboratory, Department of Physical Therapy, Avenida Jornalista Aníbal Fernandes s/n, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, 50740-560, Brazil.
Labibe Mara Pinel FredericoApplied Neuroscience Laboratory, Department of Physical Therapy, Avenida Jornalista Aníbal Fernandes s/n, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, 50740-560, Brazil.
Nathália Serrano Lucena AmaralApplied Neuroscience Laboratory, Department of Physical Therapy, Avenida Jornalista Aníbal Fernandes s/n, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, 50740-560, Brazil.
Maíra Izzadora Souza CarneiroApplied Neuroscience Laboratory, Department of Physical Therapy, Avenida Jornalista Aníbal Fernandes s/n, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, 50740-560, Brazil.
Alberto Galvão de Moura FilhoLaboratory of Kinesiology and Functional Assessment, Department of Physical Therapy, Avenida Jornalista Aníbal Fernandes s/n, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, 50740-560, Brazil.
Daniele PiscitelliSchool of Physical and Occupational Therapy, McGill University, Montreal, Canada.
Kátia Monte-SilvaApplied Neuroscience Laboratory, Department of Physical Therapy, Avenida Jornalista Aníbal Fernandes s/n, Universidade Federal de Pernambuco, Cidade Universitária, Recife, Pernambuco, 50740-560, Brazil. monte.silvakk@gmail.com.ORCID http://orcid.org/0000-0001-7301-2553
Universidade Federal de Pernambuco · BRMcGill University · CA

Funding

CNPQ 308291/2015-8FACEPE APQ-0357-4.08/13
6 · The paper itself

Abstract

objectiveRepetitive Transcranial Magnetic Stimulation (rTMS) has been used to treat post-stroke upper limb spasticity (ULS) in addition to physiotherapy (PT). To determine whether rTMS associated with PT modulates cortical and spinal cord excitability as well as decreases ULS of post-stroke patients.

methodsTwenty chronic patients were randomly assigned to either the intervention group-1 Hz rTMS on the unaffected hemisphere and PT, or control group-sham stimulation and PT, for ten sessions. Before and after sessions, ULS was measured using the modified Ashworth scale and cortical excitability using the output intensity of the magnetic stimulator (MSO). The spinal excitability was measured by the Hmax/Mmax ratio of the median nerve at baseline, at the end of treatment, and at the 4-week follow-up.

resultsThe experimental group showed at the end of treatment an enhancement of cortical excitability, i.e., lower values of MSO, compared to control group (p = 0.044) and to baseline (p = 0.028). The experimental group showed a decreased spinal cord excitability at the 4-week follow-up compared to control group (p = 0.021). ULS decreased by the sixth session in the experimental group (p < 0.05).

conclusionOne-hertz rTMS associated with PT increased the unaffected hemisphere excitability, decreased spinal excitability, and reduced post-stroke ULS.

Indexed as

Cortical ExcitabilityPhysical Therapy ModalitiesTranscranial Magnetic StimulationAgedCombined Modality TherapyDouble-Blind MethodFemaleHumansMaleMiddle AgedMuscle SpasticitySpinal CordStrokeStroke RehabilitationTreatment OutcomeUpper ExtremityH-reflexMuscle spasticityPhysical therapyStrokeTranscranial magnetic stimulationUpper extremity

Identifiers

PMID30852696
OpenAlexW2920869584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.