Evidence map›Paper›PMID 30852657›Full record

Trial reportEuropean journal of nutrition2020

Vitamin D-fortified foods improve wintertime vitamin D status in women of Danish and Pakistani origin living in Denmark: a randomized controlled trial.

Ida M Grønborg, Inge Tetens, Tue Christensen, Elisabeth W Andersen, Jette Jakobsen, Mairead Kiely, Kevin D Cashman, Rikke Andersen

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02631629 (Food-based Solutions for Optimal Vitamin D Nutrition and Health), which is not on this map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02631629 nacompletednot on this map

Food-based Solutions for Optimal Vitamin D Nutrition and Health

TypeinterventionalSponsorTechnical University of DenmarkRan2015 to 2016Enrolled143ConditionsVitamin D DeficiencyArmsNon-fortified foods, Fortified foods
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Does vitamin D supplementation reduce COVID-19 severity?: a systematic review.QJM : monthly journal of the Association of Physicians · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ida M GrønborgDivision of Nutrition, National Food Institute, Technical University of Denmark, Lyngby, Denmark. idamag@food.dtu.dk.ORCID http://orcid.org/0000-0001-7316-1073
Inge TetensDivision of Nutrition, National Food Institute, Technical University of Denmark, Lyngby, Denmark.
Tue ChristensenDivision of Nutrition, National Food Institute, Technical University of Denmark, Lyngby, Denmark.
Elisabeth W AndersenSection for Statistics and Pharmacoepidemiology, Danish Cancer Society, Copenhagen, Denmark.
Jette JakobsenDivision of Nutrition, National Food Institute, Technical University of Denmark, Lyngby, Denmark.
Mairead KielyCork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.
Kevin D CashmanCork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.
Rikke AndersenDivision of Nutrition, National Food Institute, Technical University of Denmark, Lyngby, Denmark.

Funding

FP7 International Cooperation 613977
6 · The paper itself

Abstract

purposeLow vitamin D status is prevalent worldwide. We aim to investigate the effect of vitamin D fortification on serum 25-hydroxyvitamin D (25(OH)D) concentration in women of Danish and Pakistani origin at risk of vitamin D deficiency.

methodsA 12-week randomized, double-blinded, placebo-controlled intervention trial during winter time, designed to provide 20 µg vitamin D

resultsMean (SD) baseline 25(OH)D concentrations among women of Danish and Pakistani origin were 49.6 (18) and 46.9 (22) nmol/L, respectively (P = 0.4). While 9% of Danish women had 25(OH)D < 30 nmol/L, the prevalence among women of Pakistani origin was 24%. Median (IQR) vitamin D intake among Danish and Pakistani women at endpoint was 32.0 (27.0, 34.4) µg/day and 24.2 (19.2, 30.8) µg/day, respectively. Endpoint serum 25(OH)D increased in fortified groups to 77.8 (14) nmol/L among Danish women and 54.7 (18) nmol/L among women of Pakistani origin (P < 0.01). At endpoint, 0% in the Danish-fortified group and 3% in the Pakistani-fortified group had 25(OH)D < 30 nmol/L, compared with 23 % and 34% in their respective control groups.

conclusionsVitamin D fortification of four different foods for 12 weeks during winter was effective in increasing serum 25(OH)D and reducing the prevalence of very low vitamin D status among women of Danish and Pakistani origin. CLINICALTRIALS. GOV WITH IDENTIFIER: NCT02631629.

Indexed as

SeasonsAdultDenmarkDouble-Blind MethodFemaleFood, FortifiedHumansPakistanVitamin DVitamin D DeficiencyVitamins25-hydroxyvitamin DVitamin DVitaminsFood-based RCTFortified foodsODINVitamin DWomen of Danish originWomen of Pakistani origin

Identifiers

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.