Evidence map›Paper›PMID 30852644›Full record

ArticleExperimental brain research2019

Quadriceps muscle function following anterior cruciate ligament reconstruction: systemic differences in neural and morphological characteristics.

Adam S Lepley, Dustin R Grooms, Julie P Burland, Steven M Davi, Jeffrey M Kinsella-Shaw, Lindsey K Lepley

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Experimental brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 62 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 8 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04682392 naterminatednot on this mapstarted 2021, after this paper: background citation

The Effects of Bone Health on Landing Mechanics on Patients Post ACL Reconstruction.

TypeinterventionalSponsorCandice Dunkin, MS, LAT, ATCRan2021 to 2025Enrolled19ConditionsACL TearArmsDelfi's PTS Personalized Tourniquet System for Blood Flow Restriction Group, Standard ACL rehab
NCT07406763 nacompletednot on this mapstarted 2020, after this paper: background citation

Effect of Adding Blood Flow Restriction to Traditional Program After Anterior Cruciate Ligament Reconstruction: A Double-Blinded Randomized Controlled Trial

TypeinterventionalSponsorAhmed Mohamed Mahmoud Abdelaziz KhalilRan2020 to 2022Enrolled36ConditionsBlood Flow Restriction Therapy, Anterior Cruciate Ligament (ACL)Armstraditional rehabilitation protocol, Blood Flow Restriction
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 8 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Trial
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Adam S LepleyDepartment of Kinesiology, University of Connecticut, Biology Building 4, Room 015, 3107 Horsebarn Hill Rd, 4137 Unit, Storrs, CT, 06269-4137, USA. Adam.Lepley@uconn.edu.
Dustin R GroomsOhio Musculoskeletal and Neurological Institute, Ohio University, Athens, OH, USA.
Julie P BurlandDepartment of Kinesiology, University of Connecticut, Biology Building 4, Room 015, 3107 Horsebarn Hill Rd, 4137 Unit, Storrs, CT, 06269-4137, USA.
Steven M DaviDepartment of Kinesiology, University of Connecticut, Biology Building 4, Room 015, 3107 Horsebarn Hill Rd, 4137 Unit, Storrs, CT, 06269-4137, USA.
Jeffrey M Kinsella-ShawDepartment of Kinesiology, University of Connecticut, Biology Building 4, Room 015, 3107 Horsebarn Hill Rd, 4137 Unit, Storrs, CT, 06269-4137, USA.
Lindsey K LepleyDepartment of Kinesiology, University of Connecticut, Biology Building 4, Room 015, 3107 Horsebarn Hill Rd, 4137 Unit, Storrs, CT, 06269-4137, USA.
University of Connecticut · USOhio University · USUConn Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quadriceps muscle dysfunction is common following anterior cruciate ligament reconstruction (ACLR). Data considering the diversity of neural changes, in-concert with morphological adaptations of the quadriceps muscle, are lacking. We investigated bilateral differences in neural and morphological characteristics of the quadriceps muscle in ACLR participants (n = 11, month post-surgery: 69.4 ± 22.4) compared to controls matched by sex, age, height, weight, limb dominance, and activity level. Spinal reflex excitability was assessed using Hoffmann reflexes (H:M); corticospinal excitability was quantified via active motor thresholds (AMT) and motor-evoked potentials (MEP) using transcranial magnetic stimulation. Cortical activation was assessed using a knee flexion/extension task with functional magnetic resonance imaging (fMRI). Muscle volume was quantified using structural MRI. Muscle strength and patient-reported outcomes were also collected. 2 × 2 RM ANOVAs were used to evaluate group differences. Smaller quadriceps muscle volume (total volume, rectus femoris, vastus medialis, and intermedius) and lower strength were detected compared to contralateral and control limbs. Individuals with ACLR reported higher levels of pain and fear and lower levels of knee function compared to controls. No differences were observed for H:M. ACLR individuals demonstrated higher AMT bilaterally and smaller MEPs in the injured limb, compared to the controls. ACLR participants demonstrated greater activation in frontal lobe areas responsible for motor and pain processing compared to controls, which were associated with self-reported pain. Our results suggest that individuals with ACLR demonstrate systemic neural differences compared to controls, which are observed concurrently with smaller quadriceps muscle volume, quadriceps muscle weakness, and self-reported dysfunction.

Indexed as

AdolescentAdultAnterior Cruciate Ligament ReconstructionCase-Control StudiesCross-Sectional StudiesEvoked Potentials, MotorFemaleFrontal LobeHumansMagnetic Resonance ImagingMaleMuscular AtrophyPatient Reported Outcome MeasuresQuadriceps MuscleReflex, AbnormalTranscranial Magnetic StimulationCortical activationFunctional magnetic resonance imagingMuscle atrophyQuadriceps weaknessTranscranial magnetic stimulation

Identifiers

PMID30852644
OpenAlexW2921634051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.