Evidence map›Paper›PMID 30852641›Full record

ArticleVirchows Archiv : an international journal of pathology2019

CROCC-mutated rhabdoid colorectal carcinoma showing in intercellular spaces lamellipodia and cellular projections revealed by electron microscopy.

Andrea Remo, M P Cecchini, D Benati, P Bernardi, E Manfrin, G Giordano, F Bonomi, P Parcesepe, M Fassan, R Colombari and 2 more

Abstract read
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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Andrea RemoPathology Unit, Service Department, ULSS9 "Scaligera", Via Valverde 42, 37122, Verona, Italy. remino76@yahoo.it.ORCID http://orcid.org/0000-0002-2564-2988
M P CecchiniDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Anatomy and Histology, University of Verona, Verona, Italy.
D BenatiDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Anatomy and Histology, University of Verona, Verona, Italy.
P BernardiDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Anatomy and Histology, University of Verona, Verona, Italy.
E ManfrinDepartment of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Italy.
G GiordanoOncology Division IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo Foggia, Italy.
F BonomiDepartment of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Italy.
P ParcesepeDepartment of Diagnostic and Public Health, Section of Pathology, University of Verona, Verona, Italy.
M FassanDepartment of Medicine (DIMED), University of Padua, Padua, PD, Italy.
R ColombariPathology Unit, Service Department, ULSS9 "Scaligera", Via Valverde 42, 37122, Verona, Italy.
A SbarbatiDepartment of Neurosciences, Biomedicine and Movement Sciences, Section of Anatomy and Histology, University of Verona, Verona, Italy.
M PancioneDepartment of Sciences and Technologies, University of Sannio, Benevento, Italy.
University of Verona · ITAULSS 2 Marca Trevigiana · ITCasa Sollievo della Sofferenza · ITUniversity of Padua · ITUniversity of Sannio · ITYahoo (Spain) · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRhabdoid colorectal carcinoma (RC) is a rare lesion localized to the proximal colon of patients with a mean age at diagnosis of around 70 years. This tumor shows an aggressive behavior with an overall survival period shorter than 12 months. The diagnostic hallmark is the presence of rhabdoid cells. Alterations in chromatin remodeling (SMARCB1) and in the centrosome structure (CROCC) are reported in RC usually BRAF

methodsHere, we investigated two cases of CROCC

resultsTEM confirmed the diagnostic presence of intermediate cytoplasmic filaments and nucleolar margination. SEM showed cellular protrusions (lamellipodia) in the intercellular spaces not evident at light microscopy.

conclusionsThese protrusions CROCC-related might represent the pathogenetic mechanism underlying the rhabdoid aggressive behavior, independently of tumor staging. To our knowledge, the SEM technique was applied in the study of this neoplasm for the first time.

Indexed as

AdenocarcinomaAgedColorectal NeoplasmsCytoskeletal ProteinsFemaleHumansMicroscopy, ElectronPseudopodiaRhabdoid TumorCROCC protein, humanCytoskeletal ProteinsCiliary Rootlet Coiled CoilCROCCIntermediate filamentsLamellipodiaNucleolar marginationRhabdoid colorectal carcinomaROLTScanning electron microscopySMARCB1SWI/SNFTAX1BP2Transmission electron microscopy

Identifiers

PMID30852641
OpenAlexW2921887767

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.