Evidence map›Paper›PMID 30852627›Full record

ArticleDiabetologia2019

Pregnancy in human IAPP transgenic mice recapitulates beta cell stress in type 2 diabetes.

Tatyana Gurlo, Sarah Kim, Alexandra E Butler, Chang Liu, Lina Pei, Madeline Rosenberger, Peter C Butler

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Autophagy and the pancreas: Healthy and disease states.Frontiers in cell and developmental biology · 2024
    Review
  4. Beta-cell compensation and gestational diabetes.The Journal of biological chemistry · 2023
    Review
  5. Review
  6. Mediators of Amylin Action in Metabolic Control.Journal of clinical medicine · 2022
    Review
  7. Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tatyana GurloLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, 32-150 CHS, Los Angeles, CA, 90095-7073, USA.
Sarah KimLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, 32-150 CHS, Los Angeles, CA, 90095-7073, USA.
Alexandra E ButlerLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, 32-150 CHS, Los Angeles, CA, 90095-7073, USA.
Chang LiuLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, 32-150 CHS, Los Angeles, CA, 90095-7073, USA.
Lina PeiLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, 32-150 CHS, Los Angeles, CA, 90095-7073, USA.
Madeline RosenbergerLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, 32-150 CHS, Los Angeles, CA, 90095-7073, USA.
Peter C ButlerLarry L. Hillblom Islet Research Center, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, 32-150 CHS, Los Angeles, CA, 90095-7073, USA. pbutler@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Role of IAPP in Islet Dysfunction in DiabetesR01DK059579 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUTLER, PETER CAWOOD · 2001 to 2019
$7.5M
NIDDK NIH HHS R01 DK059579
6 · The paper itself

Abstract

aims/hypothesisIslet amyloid polypeptide (IAPP) misfolding and toxic oligomers contribute to beta cell loss and stress in type 2 diabetes. Pregnancy-related diabetes predicts subsequent risk for type 2 diabetes but little is known about the impact of pregnancy on beta cell mass, turnover and stress. Availability of human pancreas tissue in pregnancy is limited and most widely used mouse models of type 2 diabetes do not develop pregnancy-related diabetes, possibly because rodent IAPP is not prone to form toxic oligomers. We hypothesised that mice transgenic for human IAPP (hIAPP) are prone to pregnancy-related diabetes with beta cell responses reflective of those in type 2 diabetes.

methodsWe evaluated the impact of a first and second pregnancy on glucose homeostasis, beta cell mass and turnover and markers of beta cell stress in hIAPP transgenic (hTG) mice.

resultsPregnancy induced both endoplasmic reticulum stress and oxidative stress and compromised autophagy in beta cells in hTG mice, which are characteristic of beta cells in type 2 diabetes. Beta cell stress persisted after pregnancy, resulting in subsequent diabetes before or during a second pregnancy. CONCLUSIONS/

interpretationHigh expression of hIAPP in response to pregnancy recapitulates mechanisms contributing to beta cell stress in type 2 diabetes. We hypothesise that, in individuals prone to type 2 diabetes, pregnancy-induced increased expression of IAPP inflicts beta cell damage that persists and is compounded by subsequent additive stress such as further pregnancy. The hTG mouse model is a novel model for pregnancy-related diabetes.

Indexed as

AnimalsAutophagyDiabetes Mellitus, Type 2Disease Models, AnimalDNA DamageEndoplasmic Reticulum StressFemaleHumansInsulinInsulin-Secreting CellsIslet Amyloid PolypeptideMiceMice, TransgenicOxidative StressPregnancyInsulinIslet Amyloid PolypeptideBeta cell massGestational diabetesPregnancyType 2 diabetes

Identifiers

PMID30852627
PMCPMC6544020
OpenAlexW2921510708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.