Evidence map›Paper›PMID 30852621›Full record

ArticleSchizophrenia bulletin2019

Social Cognition, Language, and Social Behavior in 7-Year-Old Children at Familial High-Risk of Developing Schizophrenia or Bipolar Disorder: The Danish High Risk and Resilience Study VIA 7-A Population-Based Cohort Study.

Camilla Jerlang Christiani, Jens R M Jepsen, Anne Thorup, Nicoline Hemager, Ditte Ellersgaard, Katrine S Spang, Birgitte K Burton, Maja Gregersen, Anne Søndergaard, Aja N Greve and 7 more

Abstract read
In one paragraph

Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Camilla Jerlang ChristianiMental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Jens R M JepsenMental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Anne ThorupMental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Nicoline HemagerMental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Ditte EllersgaardMental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Katrine S SpangThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Birgitte K BurtonThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Maja GregersenMental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Anne SøndergaardMental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.
Aja N GreveThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Ditte L GantriisThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Gry PoulsenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Md Jamal UddinThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Larry J SeidmanDepartment of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, Boston, MA.
Ole MorsThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Kerstin J PlessenThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, Denmark.
Merete NordentoftMental Health Centre, Mental Health Services in the Capital Region of Denmark, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo characterize social cognition, language, and social behavior as potentially shared vulnerability markers in children at familial high-risk of schizophrenia (FHR-SZ) and bipolar disorder (FHR-BP).

methodsThe Danish High-Risk and Resilience Study VIA7 is a multisite population-based cohort of 522 7-year-old children extracted from the Danish registries. The population-based controls were matched to the FHR-SZ children on age, sex, and municipality. The FHR-BP group followed same inclusion criteria. Data were collected blinded to familial high-risk status. Outcomes were social cognition, language, and social behavior.

resultsThe analysis included 202 FHR-SZ children (girls: 46%), 120 FHR-BP children (girls: 46.7%), and 200 controls (girls: 46.5%). FHR-SZ children displayed significant deficits in language (receptive: d = -0.27, P = .006; pragmatic: d = -0.51, P < .001), social responsiveness (d = -0.54, P < .001), and adaptive social functioning (d = -0.47, P < .001) compared to controls after Bonferroni correction. Compared to FHR-BP children, FHR-SZ children performed significantly poorer on adaptive social functioning (d = -0.29, P = .007) after Bonferroni correction. FHR-BP and FHR-SZ children showed no significant social cognitive impairments compared to controls after Bonferroni correction.

conclusionLanguage, social responsiveness, and adaptive social functioning deficits seem associated with FHR-SZ but not FHR-BP in this developmental phase. The pattern of results suggests adaptive social functioning impairments may not be shared between FHR-BP and FHR-SZ in this developmental phase and thus not reflective of the shared risk factors for schizophrenia and bipolar disorder.

Indexed as

Bipolar DisorderChild of Impaired ParentsLanguageSchizophreniaSocial BehaviorSocial PerceptionCase-Control StudiesChildCohort StudiesDenmarkFemaleHumansMaleRiskSocial Adjustmentfacial affect identificationlanguageneurodevelopmentoffspringsocial functioningtheory of mind

Identifiers

PMID30852621
PMCPMC6811824

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.