Evidence map›Paper›PMID 30852496›Full record

ArticleBMJ case reports2019

Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1.

Jessica Feng, Avery LaChance, David A Sinclair, Maryam M Asgari

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Cancer and Myotonic Dystrophy.Journal of clinical medicine · 2023
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Jessica FengUniversity of Massachusetts Medical School, Worcester, Massachusetts, USA.
Avery LaChanceDepartment of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
David A SinclairDepartment of Genetics, Harvard Medical School, Boston, Massachusetts, USA.
Maryam M AsgariDepartment of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Harvard University · USBrigham and Women's Hospital · USUniversity of Massachusetts Chan Medical School · US

Funding

Uncovering the Human SecretomeDP1AG058605 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2017 to 2021
$5.9M
Role of Sgs1 DNA helicase in telomere maintenanceR01AG019719 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SINCLAIR, DAVID A. · 2001 to 2022
$5.3M
SIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1M
Elucidating mechanisms of SIRT1 activationR01DK100263 · NIDDK · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2016 to 2020
$2.5M
Patient-oriented research and mentoring program in dermatologic diseasesK24AR069760 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI ASGARI, MARYAM MANDANA · 2017 to 2025
$1.9M
Nicotinamide Mononucleotide (NMN) as a Novel Therapeutic in the Treatment of Oral MucositisR21DE027490 · NIDCR · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2018 to 2019
$466k
NIAMS NIH HHS K24 AR069760NIA NIH HHS DP1 AG058605NIA NIH HHS R01 AG019719NIA NIH HHS R37 AG028730NIDCR NIH HHS R21 DE027490NIDDK NIH HHS R01 DK100263
6 · The paper itself

Abstract

A man in his early 60s with myotonic dystrophy type 1 (DM1) and an extensive history of non-melanoma skin cancer presented with multiple pearly, erythematous papules on his face, head, trunk and extremities, clinically consistent with basal cell carcinoma (BCC). Due to the numerous BCC and history of multiple and early-onset BCC, examination was concerning for a hereditary BCC syndrome. Subsequent histopathology confirmed BCC. Genetic testing was negative for basal cell nevus syndrome and clinical findings were inconsistent with other known hereditary BCC syndromes. There have been reports of an association between DM1 and BCC, however, it is not well known among clinicians. We hope to raise awareness among clinicians about this association.

Indexed as

Basal Cell CarcinomaExtremitiesFaceHeadHumansMaleMiddle AgedMyotonic DystrophySkin NeoplasmsTorsodermatologygeneticsmuscle disease

Identifiers

PMID30852496
PMCPMC6441996
OpenAlexW2922507742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.