Evidence map›Paper›PMID 30852461›Full record

ArticleJournal of reproductive immunology2019

A pilot study showing a stronger H1N1 influenza vaccination response during pregnancy in women who subsequently deliver preterm.

Sandra Andorf, Sanchita Bhattacharya, Brice Gaudilliere, Gary M Shaw, David K Stevenson, Atul J Butte, Marina Sirota

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of reproductive immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sandra AndorfStanford University School of Medicine, Stanford, CA, United States.
Sanchita BhattacharyaUniversity of California, San Francisco, San Francisco, CA, United States.
Brice GaudilliereStanford University School of Medicine, Stanford, CA, United States.
Gary M ShawStanford University School of Medicine, Stanford, CA, United States.
David K StevensonStanford University School of Medicine, Stanford, CA, United States.
Atul J ButteUniversity of California, San Francisco, San Francisco, CA, United States.
Marina SirotaUniversity of California, San Francisco, San Francisco, CA, United States. Electronic address: marina.sirota@ucsf.edu.
Stanford University · USUniversity of California, San Francisco · US

Funding

Elucidating the Role of the Genetic and Environmental Determinants of Preterm Birth Using Integrative Computational ApproachesK01LM012381 · NLM · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIROTA, MARINA · 2016 to 2018
$531k
NIAID NIH HHS HHSN272201200028CNIH HHS HHSN316201200036WNLM NIH HHS K01 LM012381
6 · The paper itself

Abstract

problemPreterm birth (PTB), or the delivery of an infant prior to 37 weeks of gestation, is a major health concern. Although a variety of social, environmental, and maternal factors have been implicated in PTB, causes of preterm labor have remained largely unknown. There is evidence of effectiveness and safety of influenza vaccination during pregnancy, however fewer studies have looked at vaccination response as an indicator of an innate host response that may be associated with adverse pregnancy outcomes. We carried out a pilot study to analyze the flu vaccine response during pregnancy of women who later deliver preterm or term. METHOD OF STUDY: We performed a secondary analysis of the individual-level data from an influenza vaccination response study (openly available from ImmPort) measured by hemagglutination inhibition assay of 91 pregnant women with term deliveries and 11 women who went on to deliver preterm. Flu vaccination responses for H1N1 and H3N2 influenza strains were compared between term and preterm deliveries.

resultsWomen who went on to deliver preterm showed a significantly (P <  0.001) greater flu vaccine response for the H1N1 strain than women who delivered at term. The vaccine response for H3N2 was not significantly different between these two groups (P =  0.97).

conclusionsAlthough the sample size is limited and additional validation is required, our findings suggest an increased activation of the maternal immune system as shown by the stronger vaccination response to H1N1 in women who subsequently delivered preterm, in comparison to women who delivered at term.

Indexed as

AdultAntibodies, ViralFemaleHumansImmunogenicity, VaccineInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza, HumanInfluenza VaccinesPilot ProjectsPregnancyPregnancy Complications, InfectiousPremature BirthSeroconversionVaccinationAntibodies, ViralInfluenza VaccinesFlu vaccination responseH1N1ImmPortPregnancy outcomesPreterm birth

Identifiers

PMID30852461
PMCPMC6456418
OpenAlexW2918443599

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.